SLPI
SLPI (secretory leukocyte peptidase inhibitor, also known as antileukoproteinase, HUSI-I, ALP, BLPI and WFDC4) is a secreted, acid-stable serine protease inhibitor that protects epithelial tissues. It also shapes inflammatory and immune responses and has antimicrobial activity. Browse Assay Genie's current range of SLPI research reagents below, or read on for the biology behind the target.
SLPI is an acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase and cathepsin G. By limiting the activity of these serine proteases it helps protect epithelial surfaces from attack by endogenous proteolytic enzymes. This is thought to be how it supports normal wound healing, since restricting protease activity probably prevents tissue damage. Together with ELANE, SLPI is also required for normal differentiation and proliferation of bone marrow myeloid cells.
Beyond protease inhibition, SLPI modulates inflammatory and immune responses. It down-regulates responses to bacterial lipopolysaccharide (LPS) and plays a role in regulating the activation of NF-kappa-B. It is antimicrobial, with reported antibacterial, antifungal and antiviral activity. It acts against mycobacteria but not salmonella, contributes to normal resistance to M. tuberculosis, and is required for normal resistance to infection by the intracellular parasite L. major.
The SLPI gene encodes a secreted protein found in seminal plasma, cervical mucus and bronchial secretions. It belongs to the HGNC gene group of WAP four-disulfide core domain containing proteins, which is reflected in the alias WFDC4. Earlier nomenclature described it as secretory leukocyte protease inhibitor (antileukoproteinase). Researchers studying SLPI use an SLPI antibody, SLPI ELISA kit or SLPI protein to examine its role in mucosal defence, inflammation and tissue repair. The mouse ortholog is Slpi.
SLPI protects epithelial tissues from serine proteases and is found in secretions such as bronchial secretions and cervical mucus.
SLPI down-regulates responses to LPS and helps regulate NF-kappa-B activation and inflammatory responses.
SLPI has antibacterial, antifungal and antiviral activity and contributes to resistance against M. tuberculosis and L. major.
SLPI is required for normal wound healing and, with ELANE, for normal myeloid cell differentiation and proliferation in bone marrow.
SLPI is a secreted serine protease inhibitor with strong affinities for trypsin, chymotrypsin, elastase and cathepsin G. It protects epithelial tissues from proteolytic damage, modulates inflammatory responses including LPS signalling and NF-kappa-B activation, and has antimicrobial activity.
SLPI is also called antileukoproteinase, HUSI-I, HUSI, ALK1, ALP, BLPI, WAP4 and WFDC4. Its earlier name was secretory leukocyte protease inhibitor (antileukoproteinase). The WFDC4 alias reflects its membership of the WAP four-disulfide core domain group.
Mouse has an ortholog, Slpi. UniProt annotates SLPI as contributing to normal resistance to M. tuberculosis and as required for normal resistance to L. major infection. Check the datasheet of any product for its validated reactivity.
Serine proteases, WAP domain proteins and inflammatory pathway targets related to SLPI biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P03973; product specifications from Assay Genie datasheets.