JUN
JUN, also known as c-Jun and AP-1, is a nuclear transcription factor of the bZIP family that binds specific DNA sequences to regulate gene expression. The gene is the human homologue of the putative transforming gene of avian sarcoma virus 17. Browse Assay Genie's current range of JUN research reagents below, or read on for the biology behind the target.
JUN encodes a protein that interacts directly with specific target DNA sequences to regulate gene expression. It is localised to the nucleus and belongs to the bZIP family, Jun subfamily. HGNC lists it within the Jun transcription factor family and names the gene product as an AP-1 transcription factor subunit, reflecting its alias AP-1.
The protein is highly similar to the viral protein encoded by avian sarcoma virus 17, whose putative transforming gene gave the locus its original names, v-jun avian sarcoma virus 17 oncogene homolog and jun oncogene. The human JUN gene is intronless. It maps to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies, which is one reason the gene is studied in cancer biology.
UniProt also records a role in microbial infection. During Epstein-Barr virus (EBV) infection, c-Jun binds the viral BZLF1 Z promoter and activates expression of viral BZLF1. Related family members with their own entries include JUNB and JUND. Mouse and rat each carry a Jun ortholog, so the gene can be studied across common model systems.
JUN binds specific target DNA sequences directly, making it a model bZIP factor for studying how AP-1 subunits control gene expression.
The gene is the homologue of a viral transforming gene and maps to a region altered in human malignancies.
c-Jun binds the EBV BZLF1 Z promoter and activates viral BZLF1 expression, linking the factor to viral gene control.
JUN belongs to the Jun subfamily alongside JUNB and JUND, allowing comparison of related AP-1 subunits.
JUN encodes a nuclear protein that interacts directly with specific target DNA sequences to regulate gene expression. It is a bZIP family transcription factor of the Jun subfamily. During EBV infection, it also binds the viral BZLF1 Z promoter and activates viral BZLF1 expression.
JUN is also called c-Jun and AP-1, and its full HGNC name is Jun proto-oncogene, AP-1 transcription factor subunit. Earlier names include v-jun avian sarcoma virus 17 oncogene homolog and jun oncogene. UniProt lists the protein as Transcription factor Jun.
Mouse and rat both have a Jun ortholog. The human gene is intronless and maps to 1p32-p31, a region involved in translocations and deletions in human malignancies. Check the datasheet of any product for its validated reactivity.
Other Jun subfamily members and AP-1 transcription factor targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P05412; product specifications from Assay Genie datasheets.