SSTR5
SSTR5 (somatostatin receptor 5) is a multi-pass cell membrane G protein-coupled receptor that binds somatostatin 28 and, to a lesser extent, somatostatin-14. Signalling through G proteins inhibits adenylyl cyclase. Browse Assay Genie's current range of SSTR5 research reagents below, or read on for the biology behind the target.
SSTR5 is a receptor for somatostatin 28 and, to a lesser extent, for somatostatin-14. Its activity is mediated by G proteins that inhibit adenylyl cyclase. Somatostatin and the related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors, and SSTR5 is one of this group.
The SSTR5 gene encodes a multi-pass membrane protein that sits in the cell membrane and belongs to the G protein-coupled receptor 1 family. HGNC places it in the somatostatin receptors gene group, alongside SSTR1, SSTR2 and SSTR3. Mouse and rat each have an orthologous Sstr5 gene. Alternatively spliced transcript variants have been identified for this gene.
Receptor interactions add a further layer of regulation. Following heterodimerisation with SSTR2, SSTR5 increases the cell growth inhibition activity of SSTR2. The NCBI Gene summary also notes that different regions of the SSTR5 molecule are required for the activation of different signalling pathways. A mutation in the SSTR5 gene has been reported to result in somatostatin analog resistance, which links the receptor to the study of responses to somatostatin-based agents.
SSTR5 binds somatostatin 28 preferentially over somatostatin-14 and acts through G proteins to inhibit adenylyl cyclase.
SSTR5 heterodimerises with SSTR2 and increases the cell growth inhibition activity of SSTR2.
Somatostatin receptors mediate actions of somatostatin and cortistatin on normal and tumoral tissue targets, making SSTR5 relevant to tumour studies.
A mutation in the SSTR5 gene results in somatostatin analog resistance, providing a focus for pharmacogenetic investigation.
SSTR5 is a cell membrane receptor for somatostatin 28 and, to a lesser extent, somatostatin-14. Its activity is mediated by G proteins that inhibit adenylyl cyclase. Different regions of the receptor are required for activating different signalling pathways.
SSTR5 is the HGNC symbol for somatostatin receptor 5, and UniProt names the protein somatostatin receptor type 5. No alternative aliases are listed. Alternatively spliced transcript variants have been identified for the SSTR5 gene.
SSTR5 belongs to the somatostatin receptor group and the G protein-coupled receptor 1 family. It heterodimerises with SSTR2 to increase that receptor's growth inhibition activity. A mutation in the SSTR5 gene results in somatostatin analog resistance. Mouse and rat Sstr5 are orthologs; check the datasheet of any product for its validated reactivity.
Other somatostatin receptors and related G protein-coupled receptor targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35346; product specifications from Assay Genie datasheets.