PACSIN3
PACSIN3 (protein kinase C and casein kinase substrate in neurons 3, also known as SDPIII) is a member of the PACSIN family that links the actin cytoskeleton with vesicle formation. It plays a role in endocytosis and regulates the internalisation of plasma membrane proteins. Browse Assay Genie's current range of PACSIN3 research reagents below, or read on for the biology behind the target.
PACSIN3 functions in endocytosis, where it regulates the internalisation of proteins from the plasma membrane. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Overexpression of PACSIN3 impairs the internalisation of SLC2A1/GLUT1 and TRPV4 and raises the levels of both proteins at the cell membrane. PACSIN3 also inhibits the calcium channel activity of TRPV4.
The PACSIN3 gene encodes a protein that belongs to the PACSIN family, which takes its name from protein kinase C and casein kinase substrate in neurons. In HGNC, the gene sits in the F-BAR domain containing and SH3 domain containing groups, and it is also listed among the microRNA protein coding host genes. The protein is found in the cytoplasm and at the cell membrane, consistent with a role at the interface between membrane and cytoskeleton. Alternative splicing of the PACSIN3 gene results in multiple transcript variants. A mouse ortholog, Pacsin3, is recognised.
SDPIII is an alternative name for the same gene. Because PACSIN3 influences how much GLUT1 and TRPV4 remains at the cell surface, it is of interest to researchers studying membrane protein trafficking, vesicle formation and the regulation of ion channel activity. Closely related family members such as PACSIN2 are often studied alongside it when comparing the roles of the PACSIN proteins.
PACSIN3 regulates the internalisation of plasma membrane proteins, making it a useful subject for studies of endocytic mechanisms.
The protein links the actin cytoskeleton with vesicle formation, which is relevant to work on cytoskeletal control of membrane dynamics.
PACSIN3 inhibits TRPV4 calcium channel activity and increases TRPV4 levels at the cell membrane, informing research on channel regulation.
Overexpression of PACSIN3 impairs GLUT1 internalisation and increases its membrane levels, relevant to studies of SLC2A1 localisation.
PACSIN3 plays a role in endocytosis and regulates the internalisation of plasma membrane proteins. It is involved in linking the actin cytoskeleton with vesicle formation. It also inhibits TRPV4 calcium channel activity, and overexpression raises GLUT1 and TRPV4 levels at the cell membrane.
Yes. SDPIII is a listed alias of the PACSIN3 gene, whose full name is protein kinase C and casein kinase substrate in neurons 3. HGNC records no previous names. NCBI notes that alternative splicing produces multiple transcript variants of the gene.
A mouse ortholog, Pacsin3, is recorded for the human gene. PACSIN3 belongs to the PACSIN family, which includes PACSIN2. Check the datasheet of any product for its validated reactivity.
Other PACSIN family members involved in membrane and cytoskeletal dynamics.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UKS6; product specifications from Assay Genie datasheets.