NPTN
NPTN (neuroplastin, also known as SDR1, GP55, GP65, np55, np65 and SDFR1) is a type I transmembrane protein of the Ig superfamily. It acts as an accessory subunit of plasma membrane calcium ATPases and as a probable cell adhesion molecule at synapses. Browse Assay Genie's current range of NPTN research reagents below, or read on for the biology behind the target.
NPTN is an accessory subunit of the plasma membrane calcium-transporting ATPase ATP2B2/PMCA2, where it stabilises the transporter at the cell surface. It also acts as a chaperone for ATP2B1, stabilising that pump and increasing its ATPase activity. In addition, neuroplastin promotes the localisation of XKR8 at the cell membrane.
Neuroplastin is a probable homophilic and heterophilic cell adhesion molecule. It is implicated in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK, and it may regulate neurite outgrowth by activating the FGFR1 signalling pathway. These activities point to a role in synaptic plasticity.
The NPTN gene encodes a type I transmembrane protein of the Ig superfamily, which is believed to take part in cell-cell or cell-substrate interactions. HGNC places it in the I-set domain containing group and the Basigin family. Alternative splicing produces multiple transcript variants, and the protein is found at the cell membrane and in the postsynaptic density. The symbol has appeared in the literature under several names, including SDR1, GP55, GP65, np55, np65 and SDFR1, and the previous HGNC name was stromal cell derived factor receptor 1. Mouse and rat both carry an orthologous Nptn gene.
NPTN is a probable contributor to synaptic plasticity and to long term potentiation at hippocampal excitatory synapses via p38MAPK.
As an accessory subunit of ATP2B2/PMCA2 and a chaperone for ATP2B1, NPTN influences the stability and activity of plasma membrane calcium ATPases.
NPTN is a probable homophilic and heterophilic adhesion molecule of the Ig superfamily, involved in cell-cell and cell-substrate interactions.
NPTN may regulate neurite outgrowth through activation of the FGFR1 signalling pathway, making it relevant to neuronal development research.
NPTN stabilises the calcium pump ATP2B2/PMCA2 at the cell surface and acts as a chaperone for ATP2B1, increasing its ATPase activity. It is also a probable cell adhesion molecule linked to long term potentiation and synaptic plasticity, and it promotes XKR8 localisation at the cell membrane.
NPTN is the HGNC symbol for neuroplastin. Aliases include SDR1, GP55, GP65, np55, np65 and SDFR1, and the earlier HGNC name was stromal cell derived factor receptor 1. Alternative splicing gives multiple transcript variants, which may account for some of the np55 and np65 naming.
Yes. Mouse and rat each have an orthologous gene named Nptn. Human NPTN belongs to the Basigin family of I-set domain containing Ig proteins. Check the datasheet of any product for its validated reactivity.
Calcium ATPases, Basigin family members and signalling partners linked to neuroplastin function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y639; product specifications from Assay Genie datasheets.