TRPM1
TRPM1 (transient receptor potential cation channel subfamily M member 1, also known as melastatin 1, LTRPC1, CSNB1C and MLSN1) is a constitutively open, calcium-permeable cation channel. It is expressed in melanocytes and is essential for the light response of retinal ON bipolar cells. Browse Assay Genie's current range of TRPM1 research reagents below, or read on for the biology behind the target.
TRPM1 forms constitutively open, nonselective divalent cation channels that mediate influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+) and Ni(2+) into the cytoplasm, leading to membrane depolarisation. The channel is impermeable to zinc ions, although TRPM1 also forms heteromultimeric channels with TRPM3 that are permeable to both calcium and zinc.
In the retina, TRPM1 is essential for the depolarising photoresponse of ON bipolar cells. In the dark, tonic glutamate release activates the G protein-coupled receptor GRM6, which releases G(o) protein and the beta-gamma G protein dimer. Both subunits can interact with and inactivate the TRPM1 channel. At light onset, glutamate release falls and GRM6 is deactivated, so the channel opens and the membrane depolarises.
The TRPM1 gene encodes a member of the transient receptor potential melastatin subfamily, which is why the protein was formerly called melastatin 1. The protein belongs to the LTrpC subfamily and is found at the cell membrane, the endoplasmic reticulum membrane and in axons. It is expressed in melanocytes and may play a role in melanin synthesis. Expression is inversely correlated with melanoma aggressiveness, so TRPM1 is used as a prognostic marker for melanoma metastasis, and it may contribute to metastasis suppression. Specific mutations in the gene cause autosomal recessive complete congenital stationary night blindness-1C. Alternate splicing produces multiple transcript variants.
TRPM1 is required for the depolarising photoresponse of ON bipolar cells and is regulated by GRM6 and G protein subunits.
TRPM1 expression is inversely correlated with melanoma aggressiveness and is used as a prognostic marker for metastasis.
Specific TRPM1 mutations cause autosomal recessive complete congenital stationary night blindness-1C.
TRPM1 is a calcium-permeable channel expressed in melanocytes that may play a role in melanin synthesis.
TRPM1 is a constitutively open cation channel that conducts divalent cations such as calcium and magnesium, causing membrane depolarisation. It is essential for the light response of retinal ON bipolar cells, and it is expressed in melanocytes, where it may play a role in melanin synthesis.
TRPM1 is also known as melastatin 1, LTRPC1, CSNB1C and MLSN1. Its full name is transient receptor potential cation channel subfamily M member 1. The gene produces multiple transcript variants through alternate splicing, so literature may describe more than one form of the TRPM1 protein.
Specific TRPM1 mutations cause autosomal recessive complete congenital stationary night blindness-1C, and low expression correlates with more aggressive melanoma. Mouse and rat both have a Trpm1 ortholog; check the datasheet of any product for its validated reactivity.
Other TRPM subfamily ion channels with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7Z4N2; product specifications from Assay Genie datasheets.