RBM26
RBM26 (RNA binding motif protein 26) is an RNA-binding protein that may be involved in the turnover of nuclear polyadenylated RNA. It is also known as PRO1777, SE70-2, ZC3H17, ARRS2 and PPP1R132, and was previously named chromosome 13 open reading frame 10. Browse Assay Genie's current range of RBM26 research reagents below, or read on for the biology behind the target.
RBM26 is an RNA-binding protein. UniProt annotates it as a protein that may be involved in the turnover of nuclear polyadenylated (pA+) RNA, and NCBI Gene lists RNA binding as its enabled activity. It is predicted to take part in RNA catabolic processes, which fits a role in the breakdown and regulation of RNA within the cell.
Localisation has not been annotated experimentally in UniProt. NCBI Gene, drawing on Alliance of Genome Resources predictions, places RBM26 in the nucleus and nucleoplasm, consistent with a function in nuclear RNA handling. The RBM26 gene is classified by HGNC in three groups: zinc fingers CCCH-type, protein phosphatase 1 regulatory subunits, and RNA binding motif containing proteins. The mouse ortholog is Rbm26.
The protein has gone by several names. Aliases include PRO1777, SE70-2, FLJ20957, ZC3H17, ARRS2 and PPP1R132, and the gene symbol was formerly C13orf10, from its original designation as chromosome 13 open reading frame 10. Researchers studying RNA metabolism and nuclear RNA decay may encounter RBM26 under any of these names, so searching on alternative identifiers is often worthwhile.
RBM26 may be involved in the turnover of nuclear polyadenylated RNA, making it a candidate for studies of how nuclear transcripts are degraded.
RBM26 is predicted to participate in RNA catabolic processes, so it is relevant to work on RNA decay and transcript regulation.
RBM26 enables RNA binding activity, supporting research into how RNA binding motif proteins recognise and associate with RNA.
RBM26 is predicted to be active in the nucleus and located in the nucleoplasm, which makes it useful for nuclear compartment studies.
RBM26 is an RNA-binding protein. UniProt states it may be involved in the turnover of nuclear polyadenylated RNA, and NCBI Gene predicts a role in RNA catabolic processes. Its function is not fully characterised, so these roles are described as possible or predicted.
RBM26 is also called RNA-binding protein 26, PRO1777, SE70-2, FLJ20957, ZC3H17, ARRS2 and PPP1R132. Its earlier gene symbol was C13orf10, from the name chromosome 13 open reading frame 10. Check all of these when searching the literature.
A mouse ortholog, Rbm26, is recorded for the human gene. No rat ortholog is given in the data used here. Researchers should check the datasheet of any product for its validated reactivity before choosing a model system.
Other RNA binding motif proteins involved in RNA processing and regulation, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5T8P6; product specifications from Assay Genie datasheets.