LIPG
LIPG, also known as endothelial lipase or EDL, is a secreted member of the lipase family that shows both phospholipase and triglyceride lipase activity. It is linked to lipoprotein metabolism and vascular biology. Browse Assay Genie's current range of LIPG research reagents below, or read on for the biology behind the target.
LIPG (lipase G, endothelial type) encodes endothelial lipase, an enzyme that exerts both phospholipase and triglyceride lipase activities. It is more active as a phospholipase than as a triglyceride lipase. As a triglyceride lipase it hydrolyses substrates with short-chain fatty acyl groups (tributyrin) and with long-chain fatty acyl groups (triolein), with similar levels of activity towards both. It also hydrolyses high density lipoproteins (HDL) more efficiently than other lipoproteins.
The LIPG gene product is a secreted protein and belongs to the AB hydrolase superfamily, within the lipase family. By sequence and by its characteristic lid region, which provides substrate specificity for enzymes of this class, it is designated a member of the TG lipase family. HGNC places the gene in the lipases group, and the enzyme carries the EC number 3.1.1.3. Orthologues of the human gene are annotated in mouse and rat, both as Lipg.
According to the NCBI Gene summary, the protein has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. Its preference for HDL as a substrate makes it a point of interest for researchers studying lipoprotein handling. The symbol EDL and the previous name "lipase, endothelial" appear in older literature, so it is worth searching under these terms alongside the current LIPG symbol.
LIPG may be involved in lipoprotein metabolism, and it hydrolyses HDL more efficiently than other lipoproteins.
The NCBI Gene summary notes that endothelial lipase may play a role in vascular biology, making it a target for vascular research.
LIPG is more active as a phospholipase than as a triglyceride lipase, which makes it a useful model for lipid substrate preference.
The lid region of TG lipase family members provides substrate specificity, so LIPG supports comparative studies within the AB hydrolase superfamily.
LIPG encodes endothelial lipase, a secreted enzyme with both phospholipase and triglyceride lipase activity. It is more active as a phospholipase, hydrolyses triglycerides with short- and long-chain acyl groups, and breaks down HDL more efficiently than other lipoproteins.
LIPG stands for lipase G, endothelial type. UniProt names the protein endothelial lipase, EDL is a listed alias, and HGNC records the previous name "lipase, endothelial". The enzyme is classified as EC 3.1.1.3 and sits in the HGNC lipases gene group.
Yes. Mouse and rat orthologues are both annotated as Lipg. The protein belongs to the AB hydrolase superfamily, lipase family, and is a TG lipase family member by sequence and lid region. Check the datasheet of any product for its validated reactivity.
Other lipases and lipoprotein-metabolism targets that may be of interest alongside endothelial lipase.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5X9; product specifications from Assay Genie datasheets.