SPR
SPR (sepiapterin reductase, also known as SDR38C1) is a cytoplasmic oxidoreductase that catalyses the final reductions in the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4). Loss of SPR function is linked to DOPA-responsive dystonia. Browse Assay Genie's current range of SPR research reagents below, or read on for the biology behind the target.
SPR catalyses the final one or two reductions in tetrahydrobiopterin biosynthesis, forming 5,6,7,8-tetrahydrobiopterin (BH4). According to the NCBI Gene summary, the enzyme carries out the NADPH-dependent reduction of pteridine derivatives, and this activity is important for BH4 production. Its systematic name, 7,8-dihydrobiopterin:NADP+ oxidoreductase, reflects the reaction it performs with NADP+ as the cofactor partner.
The SPR gene encodes a protein that belongs to the sepiapterin reductase family. HGNC places it in the short chain dehydrogenase/reductase superfamily, which explains the alias SDR38C1. The NCBI Gene summary describes the product as an aldo-keto reductase. UniProt records the protein as localised to the cytoplasm. Mouse and rat both carry an orthologous Spr gene, so rodent models are available for studying the pathway. A pseudogene has been identified on chromosome 1.
Mutations in the SPR gene result in DOPA-responsive dystonia due to sepiapterin reductase deficiency. This makes SPR a point of interest for researchers studying BH4 metabolism and the inherited disorders linked to it. Researchers working with the SPR protein often use an SPR antibody or an SPR ELISA kit to examine expression of this enzyme in cell and tissue studies.
SPR catalyses the final reductions in BH4 formation, so it is a key enzyme for studying how this pathway is controlled.
Mutations in the SPR gene cause DOPA-responsive dystonia through sepiapterin reductase deficiency, making it relevant to genetic and clinical research.
The enzyme reduces pteridine derivatives in an NADPH-dependent reaction, which makes it useful for studying pteridine biochemistry.
As a member of the short chain dehydrogenase/reductase superfamily, SPR offers a model for oxidoreductase structure and function.
SPR, or sepiapterin reductase, catalyses the final one or two reductions in the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4). It uses NADPH to reduce pteridine derivatives, and UniProt locates the enzyme in the cytoplasm.
The HGNC-approved name is sepiapterin reductase, and SDR38C1 is a recorded alias reflecting its place in the short chain dehydrogenase/reductase superfamily. Its older descriptive name is sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase). The enzyme is assigned EC 1.1.1.153.
Mutations in the SPR gene result in DOPA-responsive dystonia due to sepiapterin reductase deficiency. Mouse and rat both have an orthologous Spr gene. Check the datasheet of any product for its validated reactivity.
Other targets with products at Assay Genie that may be relevant to your work on SPR and related pathways.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35270; product specifications from Assay Genie datasheets.