GP1BB
GP1BB (glycoprotein Ib platelet subunit beta, also known as CD42c or GPIbbeta) is the beta chain of platelet glycoprotein Ib, a surface membrane protein that helps platelets bind von Willebrand factor and form platelet plugs. Browse Assay Genie's current range of GP1BB research reagents below, or read on for the biology behind the target.
GP1BB encodes the beta chain of platelet glycoprotein Ib (GPIb), a surface membrane protein of platelets. GPIb takes part in the formation of platelet plugs by binding to von Willebrand factor (VWF) that is already bound to the subendothelium. It is a heterodimeric transmembrane protein in which a disulfide-linked alpha chain and beta chain associate, and it forms part of the GPIb-V-IX system, which constitutes the receptor for VWF and mediates platelet adhesion in the arterial circulation.
Within this receptor the two chains have distinct roles. The GPIb alpha chain provides the VWF binding site, whereas GPIb beta contributes to surface expression of the receptor and participates in transmembrane signalling through phosphorylation of its intracellular domain. The 206 amino acid precursor of GPIb beta is synthesised from a 1.0 kb mRNA expressed in platelets and megakaryocytes. A longer 411 amino acid product from an unspliced transcript in endothelial cells has been described, but its authenticity has been questioned. A less abundant 3.5 kb mRNA found in non-haematopoietic tissues such as endothelium, brain and heart arises from read-through of the neighbouring upstream gene, SEPT5.
The GP1BB gene is classed by HGNC among CD molecules and human platelet antigens, and was previously named glycoprotein Ib (platelet), beta polypeptide. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder, making it a relevant target for studies of platelet adhesion and inherited platelet disorders. Mouse and rat orthologs are both named Gp1bb.
GPIb binds von Willebrand factor on the subendothelium, so GP1BB is central to studies of how platelets adhere and form plugs.
Mutations in the GPIb beta subunit are associated with Bernard-Soulier syndrome and giant platelet disorder, supporting disease-focused research.
GPIb beta contributes to surface expression of the GPIb-V-IX receptor, making it useful for studying how the complex reaches the platelet surface.
Phosphorylation of the intracellular domain of GPIb beta is involved in transmembrane signalling, a focus for platelet signalling research.
GP1BB encodes the beta chain of platelet glycoprotein Ib. As part of the GPIb-V-IX receptor for von Willebrand factor, it supports platelet adhesion. The alpha chain provides the VWF binding site, while the beta chain contributes to surface expression and transmembrane signalling.
GP1BB is also called CD42c and GPIbbeta, and its full name is glycoprotein Ib platelet subunit beta. The previous HGNC name was glycoprotein Ib (platelet), beta polypeptide. UniProt lists the protein as platelet glycoprotein Ib beta chain. Check the datasheet of any product for its validated reactivity.
Yes. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. Orthologs exist in mouse and rat, both named Gp1bb, which can be relevant when choosing a model for platelet research.
Other platelet glycoproteins, including partners in the GPIb-V-IX complex, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P13224; product specifications from Assay Genie datasheets.