MYOZ2
MYOZ2 (myozenin 2) is a sarcomeric protein of the myozenin family that anchors calcineurin at the Z line of cardiac and skeletal muscle. It is also known as CS-1, FATZ-2 and C4orf5, and it helps to modulate calcineurin signalling. Browse Assay Genie's current range of MYOZ2 research reagents below, or read on for the biology behind the target.
MYOZ2 belongs to the myozenin family of sarcomeric proteins. Myozenins are thought to act as intracellular binding proteins that link Z line components, including alpha-actinin, gamma-filamin, TCAP/telethonin and LDB3/ZASP, and that localise calcineurin signalling to the sarcomere. Calcineurin is a phosphatase involved in calcium-dependent signal transduction in many cell types. Family members tether it to alpha-actinin at the Z line of cardiac and skeletal muscle cells, so the MYOZ2 protein plays an important role in modulating calcineurin signalling. It may also contribute to myofibrillogenesis.
In the cell, myozenin-2 is found in the cytoplasm, within the myofibril, at the sarcomere Z line. The MYOZ2 gene is listed by HGNC in the myozenins gene group, and the mouse ortholog is Myoz2.
The gene has also been known as CS-1, FATZ-2 and C4orf5, the last being the previous symbol from its former name, chromosome 4 open reading frame 5. Mutations in the MYOZ2 gene cause familial hypertrophic cardiomyopathy type 16, a hereditary heart disorder, which makes the protein a point of interest for studies of how Z line scaffolding and calcineurin signalling relate to cardiac disease.
MYOZ2 localises calcineurin to the sarcomere and modulates its signalling, making it a relevant target for studying calcium-dependent phosphatase pathways in muscle.
Myozenin-2 links Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin and LDB3/ZASP, so it is useful for studying Z line organisation.
Mutations in MYOZ2 cause familial hypertrophic cardiomyopathy type 16, linking the gene to inherited heart disease.
MYOZ2 may play a role in myofibrillogenesis, the assembly of myofibrils in cardiac and skeletal muscle cells.
MYOZ2 is a sarcomeric protein that may serve as an intracellular binding protein at the Z line. It links proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin and LDB3/ZASP, tethers calcineurin to alpha-actinin, and plays an important role in modulating calcineurin signalling.
The HGNC name is myozenin 2, and UniProt lists the protein as myozenin-2. Aliases include CS-1 and FATZ-2. The previous symbol was C4orf5, from the earlier name chromosome 4 open reading frame 5. It is a member of the myozenin family.
Yes. Mutations in the MYOZ2 gene cause familial hypertrophic cardiomyopathy type 16, a hereditary heart disorder. The mouse ortholog is Myoz2. Check the datasheet of any product for its validated reactivity.
Other myozenins, Z line proteins and calcineurin pathway components relevant to muscle biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NPC6; product specifications from Assay Genie datasheets.