ABCC6
ABCC6 (ATP-binding cassette sub-family C member 6, also known as MRP6) is a member of the ABC transporter superfamily and the MRP subfamily. It is linked to multi-drug resistance, and mutations in the ABCC6 gene cause pseudoxanthoma elasticum. Browse Assay Genie's current range of ABCC6 research reagents below, or read on for the biology behind the target.
ABCC6 belongs to the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes. It sits in the ABCC family and the conjugate transporter subfamily (TC 3.A.1.208), and the NCBI Gene summary places it in the MRP subfamily, where it is involved in multi-drug resistance. UniProt also annotates a function in which the protein inhibits TNF-mediated apoptosis by blocking one or more caspases.
In UniProt, the ABCC6 protein is localised to the basal and basolateral cell membrane and to the endoplasmic reticulum membrane. The gene is classed by HGNC in the ATP binding cassette subfamily C group. Orthologues are named Abcc6 in both mouse and rat, which allows the gene to be studied in rodent models. Alternatively spliced transcript variants that encode different proteins have been described for this gene, so researchers should consider which form their assay is designed to detect.
The gene has had several names. Its previous HGNC name, pseudoxanthoma elasticum, reflects its disease association, and aliases include MRP6, MLP1, URG7, ARA and PXE. Mutations in ABCC6 cause pseudoxanthoma elasticum. The older name, ATP-binding cassette, sub-family C (CFTR/MRP), member 6, shows its place among the CFTR/MRP-type transporters. Studies of the ABCC6 gene therefore span membrane transport biology, drug resistance and heritable disease.
Mutations in the ABCC6 gene cause pseudoxanthoma elasticum, making the protein a central focus for studies of this inherited disorder.
As an MRP-subfamily ABC transporter, ABCC6 is involved in multi-drug resistance and is relevant to work on how cells handle transported molecules.
ABC proteins move molecules across extra- and intracellular membranes, and ABCC6 is a conjugate transporter in the ABCC family.
UniProt reports that ABCC6 inhibits TNF-mediated apoptosis by blocking one or more caspases, linking it to cell death regulation.
ABCC6 is an ABC transporter of the MRP subfamily, and ABC proteins transport molecules across cellular membranes. It is involved in multi-drug resistance. UniProt also records that it inhibits TNF-mediated apoptosis by blocking one or more caspases.
ABCC6 is also called MRP6, MLP1, URG7, ARA, PXE and EST349056. Its previous names are pseudoxanthoma elasticum and ATP-binding cassette, sub-family C (CFTR/MRP), member 6. Alternatively spliced transcript variants encoding different proteins have been described.
Mutations in ABCC6 cause pseudoxanthoma elasticum. Mouse and rat both have an orthologue named Abcc6. For cross-species work, check the datasheet of any product for its validated reactivity.
Other ABCC-family transporters and MRP-subfamily members that are relevant to ABCC6 research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95255; product specifications from Assay Genie datasheets.