GK3
GK3 (glycerol kinase 3) is a member of the FGGY kinase family and is predicted to have glycerol kinase activity. It is also known as GKTB, GKP3 and GK3P, and may be involved in the regulation of glycerol uptake and metabolism. Browse Assay Genie's current range of GK3 research reagents below, or read on for the biology behind the target.
GK3 is a glycerol kinase, classified under EC 2.7.1.30 and placed in the FGGY kinase family. Glycerol kinases act on glycerol, and the NCBI Gene summary predicts that GK3 enables glycerol kinase activity. UniProt annotates the protein as one that may be involved in the regulation of glycerol uptake and metabolism, so its role is described as possible rather than firmly established.
The glycerol kinase 3 protein is annotated to the outer membrane of the mitochondrion and to the cytosol. The NCBI Gene summary also reports that it is located in mitochondrion. Based on predicted function, GK3 is linked to the glycerol metabolic process, the glycerol-3-phosphate biosynthetic process and the triglyceride metabolic process, which places it in the handling of glycerol and lipid-related metabolites.
The GK3 gene is listed by HGNC within the glycerol kinase family and the FGGY kinase family. Its history is reflected in its names: earlier HGNC entries call it glycerol kinase pseudogene 3 and glycerol kinase 3 pseudogene, and the aliases GKTB, GKP3 and GK3P are still in use in the literature and databases. Researchers searching for GK3 should be aware of these older designations when comparing sources. The paralogous glycerol kinase gene, GK, is a related target to consult for comparison.
GK3 is predicted to have glycerol kinase activity and may regulate glycerol uptake and metabolism, making it relevant to studies of glycerol handling.
Predicted involvement in glycerol-3-phosphate biosynthesis and triglyceride metabolic processes ties GK3 to research on lipid precursors and storage.
GK3 is annotated to the mitochondrial outer membrane and cytosol, providing a basis for work on how metabolic enzymes are distributed within cells.
As an FGGY family member related to glycerol kinase, GK3 supports comparative studies of paralogues and of gene nomenclature history.
GK3 is predicted to enable glycerol kinase activity and to take part in glycerol metabolism, glycerol-3-phosphate biosynthesis and triglyceride metabolism. UniProt states that it may be involved in the regulation of glycerol uptake and metabolism. These functions are predicted rather than fully characterised.
GK3 is the approved HGNC symbol for glycerol kinase 3. Aliases and previous symbols include GKTB, GKP3 and GK3P, and earlier names were glycerol kinase pseudogene 3 and glycerol kinase 3 pseudogene. Check all of these when searching literature and databases.
UniProt lists the GK3 protein in the mitochondrion outer membrane and in the cytosol. The NCBI Gene summary likewise reports it as located in mitochondrion. Mouse and rat orthologs are not given in the data, so check the datasheet of any product for its validated reactivity.
Glycerol kinase and other targets with similar gene symbols that have pages at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14409; product specifications from Assay Genie datasheets.