PPP2R5E
PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon, also known as B56E or B56epsilon) is the epsilon isoform of the B56 family of regulatory subunits of protein phosphatase 2A. It is thought to influence substrate selectivity and the localisation of the PP2A enzyme. Browse Assay Genie's current range of PPP2R5E research reagents below, or read on for the biology behind the target.
PPP2R5E is a regulatory subunit of protein phosphatase 2A (PP2A), one of the four major Ser/Thr phosphatases, which is implicated in the negative control of cell growth and division. PP2A is built around a common heteromeric core enzyme, made up of a catalytic subunit and a constant regulatory subunit, and this core associates with a variety of further regulatory subunits. The B regulatory subunit, of which PPP2R5E is one example, might modulate substrate selectivity and catalytic activity, and might also direct the catalytic enzyme to a particular subcellular compartment.
The PPP2R5E gene encodes the epsilon isoform of the B56 subfamily of regulatory subunits, and the protein belongs to the phosphatase 2A regulatory subunit B56 family. UniProt annotates the protein as cytoplasmic. Multiple transcript variants encoding several different isoforms have been reported for this gene, so researchers studying PPP2R5E protein should consider which variant is relevant to their experiment. A mouse ortholog, Ppp2r5e, is recognised.
HGNC places the gene in the groups of protein phosphatase 2 regulatory subunits and armadillo like helical domain containing proteins. Its earlier name was protein phosphatase 2, regulatory subunit B (B56), epsilon isoform, and B56E and B56epsilon remain in use as aliases. Because the regulatory subunit contributes to how PP2A is targeted, PPP2R5E is relevant to work on how a single catalytic enzyme is directed towards different substrates.
PPP2R5E is one of the variable regulatory subunits that associate with the PP2A core enzyme, making it relevant to studies of holoenzyme composition.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, a question central to understanding how PP2A acts on specific targets.
Regulatory subunits might direct the catalytic enzyme to a particular subcellular compartment, and PPP2R5E is annotated as cytoplasmic.
PP2A is implicated in the negative control of cell growth and division, placing its regulatory subunits in cell cycle and proliferation research.
PPP2R5E is a B56 family regulatory subunit of protein phosphatase 2A. Regulatory subunits of this type might modulate substrate selectivity and catalytic activity, and might direct the catalytic enzyme to a particular subcellular compartment. PP2A itself is implicated in the negative control of cell growth and division.
PPP2R5E is also called B56E or B56epsilon, and was previously named protein phosphatase 2, regulatory subunit B (B56), epsilon isoform. The gene is reported to give rise to multiple transcript variants encoding several different isoforms, so check which one your work addresses.
A mouse ortholog, Ppp2r5e, is recognised for the human gene. The protein belongs to the phosphatase 2A regulatory subunit B56 family, and HGNC lists it among the protein phosphatase 2 regulatory subunits. Check the datasheet of any product for its validated reactivity.
Other PP2A subunits, related Ser/Thr phosphatase catalytic and regulatory subunits with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16537; product specifications from Assay Genie datasheets.