MED31
MED31 (mediator complex subunit 31, also known as CGI-125 or Soh1) is a nuclear component of the Mediator complex, a coactivator that supports regulated transcription by RNA polymerase II. It belongs to the Mediator complex subunit 31 family. Browse Assay Genie's current range of MED31 research reagents below, or read on for the biology behind the target.
MED31 is a subunit of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator acts as a bridge, conveying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. It is recruited to promoters through direct interactions with regulatory proteins, and it serves as a scaffold for assembling a functional preinitiation complex with RNA polymerase II and the general transcription factors.
The human MED31 gene encodes the Mediator of RNA polymerase II transcription subunit 31, a protein that localises to the nucleus. HGNC places the gene in the Mediator complex group, and the mouse ortholog is Med31. The gene has also been known as CGI-125 and Soh1, and its previous name was mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae), which reflects its yeast counterpart.
NCBI Gene summary entries for MED31 are predictions rather than direct experimental statements. The gene is predicted to enable transcription coregulator activity and to be involved in regulation of transcription by RNA polymerase II. It is also predicted to contribute to ubiquitin protein ligase activity, and to act upstream of or within limb development and negative regulation of fibroblast proliferation. Researchers studying the MED31 gene or protein should treat these roles as annotations to be tested in their own systems.
MED31 is part of Mediator, which relays signals from regulatory proteins to RNA polymerase II and supports regulated transcription of nearly all Pol II-dependent genes.
Mediator acts as a scaffold for assembling a functional preinitiation complex with RNA polymerase II and the general transcription factors, making MED31 relevant to promoter studies.
As a defined member of the Mediator complex group, MED31 is a useful subject for work on how individual subunits contribute to coactivator architecture.
MED31 is predicted to act upstream of or within limb development and negative regulation of fibroblast proliferation, suggesting directions for functional study.
MED31 is a subunit of the Mediator complex, a coactivator for regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator bridges gene-specific regulatory proteins and the basal Pol II machinery, and acts as a scaffold for preinitiation complex assembly. MED31 is found in the nucleus.
MED31 is also known as CGI-125 and Soh1. Its UniProt name is Mediator of RNA polymerase II transcription subunit 31. A former HGNC name was mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae), reflecting the yeast homologue.
Yes. The mouse ortholog is Med31, and the earlier HGNC name refers to an S. cerevisiae homolog, which indicates conservation of this Mediator subunit. Check the datasheet of any product for its validated reactivity.
Other Mediator complex subunits and related transcription-associated targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y3C7; product specifications from Assay Genie datasheets.