CLEC9A
CLEC9A (C-type lectin domain containing 9A, also known as DNGR-1 and CD370) is a membrane-bound endocytic receptor on a small subset of myeloid cells. It recognises exposed filamentous actin on damaged cells and supports the processing of dead-cell material. Browse Assay Genie's current range of CLEC9A research reagents below, or read on for the biology behind the target.
CLEC9A functions as an endocytic receptor on a small subset of myeloid cells that are specialised for the uptake and processing of material from dead cells. It recognises the filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin. These structures become exposed when cell membranes are damaged, so the receptor acts as a sensor of cell death. Through this recognition, CLEC9A mediates the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
NCBI Gene describes CLEC9A as a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells. The protein is a membrane receptor encoded by the CLEC9A gene. HGNC places it in the CD molecules group, the C-type lectin domain containing group and the Dectin 1 cluster, which places it close to other myeloid C-type lectin receptors such as CLEC7A.
The protein has been known under several names. DNGR-1 and CD370 are commonly used aliases, and UNQ9341 and HEEE9341 appear as further identifiers. Its official name, C-type lectin domain containing 9A, was previously written as C-type lectin domain family 9, member A. Mouse and rat both carry a Clec9a ortholog, which allows the biology of dead-cell sensing and antigen cross-presentation to be studied in rodent systems.
CLEC9A detects filamentous actin exposed when cell membranes are damaged, making it a model receptor for studying how myeloid cells sense dead cells.
The receptor mediates cross-presentation of dead-cell associated antigens in a Syk-dependent manner, relevant to studies of antigen processing.
CLEC9A is expressed on a small subset of myeloid lineage cells, so it is useful for characterising specialised myeloid populations.
As a group V C-type lectin-like activation receptor in the Dectin 1 cluster, CLEC9A supports comparative work across the CLEC receptor family.
CLEC9A is an endocytic receptor on a small subset of myeloid cells that take up and process material from dead cells. It binds filamentous actin exposed on damaged membranes and mediates cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
CLEC9A is also called DNGR-1 and CD370. Further identifiers include UNQ9341 and HEEE9341. The full name is C-type lectin domain containing 9A, previously written as C-type lectin domain family 9, member A. Check the datasheet of any product for its validated reactivity.
Mouse and rat both have a Clec9a ortholog. NCBI Gene classifies CLEC9A as a group V C-type lectin-like receptor that acts as an activation receptor on myeloid lineage cells, and HGNC places it in the Dectin 1 cluster.
Other C-type lectin domain family members, including Dectin 1 cluster receptors and myeloid lectins, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UXN8; product specifications from Assay Genie datasheets.