SREBF2
SREBF2, also known as SREBP2 or bHLHd2, is a key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. It binds the sterol regulatory element 1 motif and controls cholesterol homeostasis through sterol-regulated gene transcription. Browse Assay Genie's current range of SREBF2 research reagents below, or read on for the biology behind the target.
SREBF2 is a key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. It binds the sterol regulatory element 1 (SRE-1), with the sequence 5'-ATCACCCCAC-3'. It also shows dual sequence specificity, binding an E-box motif (5'-ATCACGTGA-3') as well as SRE-1. Through these interactions it regulates transcription of genes related to the cholesterol synthesis pathway, and in this way controls cholesterol homeostasis by regulating sterol-regulated genes.
The SREBF2 gene encodes a ubiquitously expressed protein that contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. It belongs to the SREBP family. UniProt records its subcellular locations as the endoplasmic reticulum membrane, the Golgi apparatus membrane, COPII-coated vesicle membrane in the cytoplasm, and the nucleus. Alternate splicing of the gene results in multiple transcript variants. Mouse and rat both have an orthologous Srebf2 gene.
HGNC places SREBF2 in the basic helix-loop-helix proteins, the sterol regulatory element binding transcription factor family, and the group of microRNA protein coding host genes. It is commonly referred to as SREBP2 or bHLHd2. Researchers studying SREBF2 often consider it alongside SREBF1, its fellow member of the sterol regulatory element binding transcription factor family.
SREBF2 regulates transcription of genes in the cholesterol synthesis pathway, making it a central subject in studies of sterol metabolism.
As a ubiquitously expressed factor controlling sterol-regulated genes, SREBF2 is used to examine how cells maintain cholesterol balance.
SREBF2 binds both SRE-1 and an E-box motif, offering a model for DNA sequence recognition by bHLH-Zip factors.
SREBF2 is found in the ER, Golgi and COPII-coated vesicle membranes as well as the nucleus, relevant to studies of its subcellular distribution.
SREBF2 is a transcription factor that regulates expression of genes involved in cholesterol biosynthesis. It binds the sterol regulatory element 1 motif and an E-box motif, and controls cholesterol homeostasis by regulating transcription of sterol-regulated genes.
SREBF2 is also called SREBP2 and bHLHd2, and its full name is sterol regulatory element binding transcription factor 2. NCBI Gene notes that alternate splicing results in multiple transcript variants. HGNC lists no previous names for the symbol.
Yes. Mouse and rat both carry an orthologous gene named Srebf2. The human protein belongs to the SREBP family, alongside SREBF1. Check the datasheet of any product for its validated reactivity.
Other members of the sterol regulatory element binding transcription factor family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12772; product specifications from Assay Genie datasheets.