XPNPEP1
XPNPEP1 (X-prolyl aminopeptidase 1, also known as Xaa-Pro aminopeptidase 1, XPNPEP or XPNPEPL1) is a cytosolic metalloaminopeptidase. It removes the penultimate prolyl residue from the N-termini of peptides and contributes to the degradation of bradykinin. Browse Assay Genie's current range of XPNPEP1 research reagents below, or read on for the biology behind the target.
XPNPEP1 is a metalloaminopeptidase that catalyses the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. In other words, it cleaves the N-terminal amino acid when it sits next to a proline. This activity is relevant because proline-containing peptide bonds resist many other peptidases. The enzyme contributes to the degradation of bradykinin, and the NCBI Gene summary notes that it may also play a role in the degradation and maturation of tachykinins, neuropeptides and peptide hormones.
The XPNPEP1 gene encodes the cytosolic form of the enzyme, and the protein is annotated to the cytoplasm, specifically the cytosol. Alternative splicing of the gene results in multiple transcript variants. The XPNPEP1 protein belongs to the peptidase M24B family, and HGNC places it in the aminopeptidase group and the M24 metallopeptidase family. The enzyme carries the EC number 3.4.11.9. Mouse and rat each have an orthologous gene, Xpnpep1.
The gene has been listed under several names. Earlier HGNC names include X-prolyl aminopeptidase (aminopeptidase P)-like and X-prolyl aminopeptidase (aminopeptidase P) 1, soluble, and the aliases XPNPEP, XPNPEPL1 and XPNPEPL are still found in the literature. The name aminopeptidase P reflects the same Xaa-Pro cleavage activity. The related genes XPNPEP2 and XPNPEP3 encode other X-prolyl aminopeptidases, so it is worth confirming which family member a given reagent or study addresses.
XPNPEP1 contributes to bradykinin degradation, making it a relevant enzyme for studying how this peptide is processed.
The enzyme may take part in the degradation and maturation of tachykinins and other neuropeptides.
XPNPEP1 may contribute to the degradation and maturation of peptide hormones through N-terminal proline-adjacent cleavage.
As an M24B family metalloaminopeptidase, XPNPEP1 is a model for studying removal of N-terminal residues next to proline.
XPNPEP1 is a metalloaminopeptidase that removes a penultimate prolyl residue from peptide N-termini, for example in Arg-Pro-Pro. It contributes to the degradation of bradykinin and may play a role in the degradation and maturation of tachykinins, neuropeptides and peptide hormones.
The HGNC name is X-prolyl aminopeptidase 1, and UniProt calls it Xaa-Pro aminopeptidase 1. Aliases include XPNPEP, XPNPEPL1 and XPNPEPL. Earlier names were X-prolyl aminopeptidase (aminopeptidase P)-like and aminopeptidase P 1, soluble. Alternative splicing gives multiple transcript variants.
Yes. Mouse and rat both have an orthologous gene named Xpnpep1. The human protein belongs to the peptidase M24B family. Related human genes XPNPEP2 and XPNPEP3 encode other X-prolyl aminopeptidases; check the datasheet of any product for its validated reactivity.
Other X-prolyl aminopeptidase family members with targets at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NQW7; product specifications from Assay Genie datasheets.