PPIC
PPIC (peptidylprolyl isomerase C, also known as CYPC) is a cytoplasmic cyclophilin-type peptidyl-prolyl cis-trans isomerase. It catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Browse Assay Genie's current range of PPIC research reagents below, or read on for the biology behind the target.
PPIC is a peptidyl-prolyl cis-trans isomerase (PPIase). Enzymes of this type catalyse the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides, a step that can limit the rate at which a polypeptide chain reaches its folded state. By accelerating this conversion, PPIC may assist protein folding. The protein is annotated as localising to the cytoplasm.
The PPIC gene encodes a member of the cyclophilin-type PPIase family, and HGNC places it in the cyclophilin peptidylprolyl isomerases gene group. Like other cyclophilins, the PPIC protein can bind the immunosuppressant cyclosporin A. The enzyme carries the EC number 5.2.1.8, and the mouse ortholog is designated Ppic.
The protein is also known as cyclophilin C, and CYPC is a recognised alias for the gene. Researchers studying PPIC often place it alongside other cyclophilins when examining proline isomerisation, protein folding and cyclosporin A binding. For reference, the identifiers are HGNC:9256, NCBI Gene 5480 and UniProt P45877.
PPIC catalyses proline cis-trans isomerisation and may assist protein folding, making it relevant to studies of how proline-containing peptides reach their native conformation.
As a cyclophilin-type PPIase, PPIC provides a point of comparison with other family members in work on shared catalytic activity and cyclosporin A binding.
PPIC binds the immunosuppressant cyclosporin A, as other PPIases do, which makes it of interest in studies of cyclophilin-drug binding.
With its defined activity under EC 5.2.1.8, PPIC is a suitable subject for investigating the mechanism of peptidyl-prolyl isomerisation in oligopeptides.
PPIC is a PPIase that catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. It is a member of the cyclophilin-type PPIase family and is found in the cytoplasm.
The gene symbol is PPIC, and HGNC gives the full name as peptidylprolyl isomerase C. CYPC is a listed alias, and the protein is known as cyclophilin C. UniProt names it peptidyl-prolyl cis-trans isomerase C.
The mouse ortholog is Ppic. Like other PPIases, the PPIC protein can bind the immunosuppressant cyclosporin A, a property shared across the cyclophilin family. Check the datasheet of any product for its validated reactivity.
Other cyclophilin peptidylprolyl isomerases and protein-folding enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P45877; product specifications from Assay Genie datasheets.