PLIN4
PLIN4 (perilipin 4, also known as S3-12 and KIAA1881) is a member of the perilipin family of proteins that coat intracellular lipid storage droplets. It may contribute to triacylglycerol packaging in adipocytes and to the biogenesis of lipid droplets. Browse Assay Genie's current range of PLIN4 research reagents below, or read on for the biology behind the target.
PLIN4 is a member of the perilipin family, whose members coat intracellular lipid storage droplets. UniProt annotates it as a protein that may play a role in triacylglycerol packaging into adipocytes, and that may function as a coat protein involved in the biogenesis of lipid droplets. These roles are described as probable rather than established, so PLIN4 is best studied alongside other lipid droplet markers when interpreting results.
The PLIN4 gene encodes the protein perilipin-4, a large protein of the perilipin family. According to UniProt, it is found at the lipid droplet, in the cytoplasm and at the cell membrane. The mouse ortholog is Plin4, which allows the biology of this protein to be examined in murine models. Researchers working with a PLIN4 antibody, PLIN4 ELISA kit or recombinant PLIN4 protein typically do so to examine lipid droplet composition and neutral lipid storage.
The gene is classified by HGNC within the Perilipins gene group. Its original designation, S3-12, remains in use in the literature, and the previous symbol KIAA1881 may also be encountered in older records. The NCBI Gene summary cites the work of Wolins and colleagues in describing perilipin family members, including PLIN4, as coats of intracellular lipid storage droplets. Related family members such as PLIN1, PLIN2 and PLIN3 are often studied in the same context.
PLIN4 is a perilipin family protein that coats intracellular lipid storage droplets, making it relevant to studies of droplet structure and composition.
PLIN4 may play a role in triacylglycerol packaging into adipocytes, linking it to research on fat storage.
PLIN4 may act as a coat protein involved in the biogenesis of lipid droplets, which is relevant to how droplets form.
As a perilipin family member, PLIN4 can be studied alongside PLIN1, PLIN2 and PLIN3 to compare droplet coat proteins.
PLIN4 is a perilipin family protein that coats intracellular lipid storage droplets. UniProt notes that it may play a role in triacylglycerol packaging into adipocytes and may function as a coat protein involved in the biogenesis of lipid droplets. These functions are described as possible.
PLIN4 stands for perilipin 4, and the UniProt protein name is perilipin-4. It is also known as S3-12, and its previous HGNC symbol was KIAA1881. HGNC places it in the Perilipins gene group, so these names may all appear in older literature.
The mouse ortholog is Plin4, so the protein can be studied in murine systems. Perilipin family members are described as lipid droplet coat proteins. For any species, check the datasheet of any product for its validated reactivity.
Other perilipin family members and lipid droplet coat proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96Q06; product specifications from Assay Genie datasheets.