CLEC11A
CLEC11A (C-type lectin domain containing 11A) is a secreted sulfated glycoprotein of the C-type lectin superfamily that acts as a growth factor for primitive haematopoietic progenitor cells and promotes osteogenesis. It is also known as P47, LSLCL, CLECSF3 and SCGF. Browse Assay Genie's current range of CLEC11A research reagents below, or read on for the biology behind the target.
CLEC11A is a secreted sulfated glycoprotein that functions as a growth factor for primitive haematopoietic progenitor cells. It also promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts, and it is important for the repair and maintenance of adult bone. These two activities place the protein at the interface of the blood-forming and skeletal systems.
The CLEC11A gene encodes a member of the C-type lectin superfamily and belongs to the HGUC-defined group of C-type lectin domain containing genes. UniProt lists the protein in both the cytoplasm and the secreted compartment, consistent with its role as an extracellular growth factor. RefSeq notes that an alternative splice variant has been described, although its biological nature has not been determined. Orthologues are annotated in mouse and rat as Clec11a, which supports work in rodent models of bone and haematopoietic biology.
The protein has been known under several names, reflecting its history. Previous names include stem cell growth factor (hence the alias SCGF) and lymphocyte secreted C-type lectin (LSLCL), while other aliases are P47 and CLECSF3. Researchers studying CLEC11A, whether through the CLEC11A gene, the CLEC11A protein, or by immunodetection with a CLEC11A antibody or CLEC11A ELISA kit, will often meet these older designations in the literature.
CLEC11A promotes the differentiation of mesenchymal progenitors into mature osteoblasts, making it relevant to studies of osteogenesis.
The protein is important for the repair and maintenance of adult bone, supporting research into skeletal homeostasis and regeneration.
CLEC11A functions as a growth factor for primitive haematopoietic progenitor cells, so it is studied in progenitor growth and stem cell biology.
As a secreted sulfated glycoprotein of the C-type lectin superfamily, CLEC11A offers a point of comparison with membrane-bound lectin family members.
CLEC11A is a secreted sulfated glycoprotein that acts as a growth factor for primitive haematopoietic progenitor cells. It also promotes osteogenesis by driving mesenchymal progenitors to differentiate into mature osteoblasts, and it is important for repairing and maintaining adult bone.
CLEC11A is also called P47, LSLCL, CLECSF3 and SCGF. Earlier names include stem cell growth factor and lymphocyte secreted C-type lectin. The HGNC name is C-type lectin domain containing 11A. RefSeq also describes an alternative splice variant whose biological nature is undetermined.
Yes, orthologues are annotated in mouse and rat, both named Clec11a, so rodent systems can be used to study its roles in bone and haematopoiesis. Check the datasheet of any product for its validated reactivity.
Other C-type lectin domain containing proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y240; product specifications from Assay Genie datasheets.