CDH6
CDH6 (cadherin 6) is a type II classical cadherin, a calcium-dependent cell adhesion protein found in the cell membrane. It was previously named K-cadherin (foetal kidney) and mediates homophilic cell-cell adhesion. Browse Assay Genie's current range of CDH6 research reagents below, or read on for the biology behind the target.
CDH6 is a calcium-dependent cell adhesion protein. Like other cadherins, it preferentially interacts with itself in a homophilic manner when connecting cells, so cadherins may contribute to the sorting of heterogeneous cell types. Cadherins are membrane glycoproteins, and CDH6 is localised to the cell membrane, where it mediates cell-cell adhesion and supports roles in cell differentiation and morphogenesis.
The CDH6 gene encodes a member of the cadherin superfamily. HGNC places it in the type II classical cadherins group. Orthologous genes are present in mouse and rat, both named Cdh6, which allows the CDH6 protein to be studied in common model organisms.
The gene was formerly listed as cadherin 6, type 2, and as K-cadherin (foetal kidney), a name that reflects its link to the kidney. According to the NCBI Gene summary, the encoded protein may play a role in kidney development as well as in endometrium and placenta formation. Decreased expression of the CDH6 gene may be associated with tumour growth and metastasis, which makes it of interest in studies of adhesion in cancer. Researchers looking at CDH6 antibody, CDH6 ELISA kit or recombinant CDH6 protein tools are usually addressing questions of tissue organisation, development or tumour biology.
CDH6 mediates calcium-dependent homophilic cell-cell adhesion, making it a useful model for how cadherins connect cells.
CDH6 may play a role in kidney development, and it was originally named K-cadherin (foetal kidney).
CDH6 may contribute to endometrium and placenta formation, linking cadherin adhesion to reproductive tissue biology.
Decreased CDH6 expression may be associated with tumour growth and metastasis, so it is studied in cancer progression.
CDH6 is a calcium-dependent cell adhesion protein of the type II cadherin class. It interacts preferentially with itself in a homophilic manner to connect cells, and may contribute to the sorting of different cell types. It is implicated in differentiation and morphogenesis.
The HGNC full name is cadherin 6. Earlier names were cadherin 6, type 2, and K-cadherin (foetal kidney). UniProt lists the protein as Cadherin-6. No alternative gene symbols are recorded, so CDH6 is the standard symbol.
Mouse and rat each have an ortholog named Cdh6. The NCBI Gene summary says decreased expression may be associated with tumour growth and metastasis. Check the datasheet of any product for its validated reactivity.
Other cadherin family members and cell adhesion targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P55285; product specifications from Assay Genie datasheets.