CMKLR1
CMKLR1 (chemerin chemokine-like receptor 1) is a cell membrane receptor of the chemokine-like receptor family and a member of the HGNC chemerin receptors group. It is also known as ChemR23, RVER1 and ERV1. Browse Assay Genie's current range of CMKLR1 research reagents below, or read on for the biology behind the target.
CMKLR1 is a receptor located in the plasma membrane. According to NCBI Gene, it is involved in chemotaxis, including positive regulation of macrophage chemotaxis, and in the regulation of calcium-mediated signalling. The same record lists adipokinetic hormone binding and adipokinetic hormone receptor activity among its molecular functions. These annotations place CMKLR1 at the interface between extracellular ligand recognition and intracellular signalling in immune and related cell types.
UniProt classifies the protein, named Chemerin-like receptor 1, as a member of the chemokine-like receptor (CMKLR) family. HGNC places the CMKLR1 gene in the chemerin receptors group, and its approved name, chemerin chemokine-like receptor 1, reflects this relationship. Researchers studying the CMKLR1 protein often work on macrophage migration, calcium signalling and chemerin-driven pathways.
The receptor has gone by several names. HGNC records the previous name chemokine-like receptor 1, and the aliases RVER1, ERV1 and ChemR23 appear in the literature. Mouse and rat both carry an ortholog named Cmklr1, so the CMKLR1 gene can be examined in common rodent models.
CMKLR1 also has a documented role in microbial infection. UniProt reports that it acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A) and for a primary HIV-1 strain, 92UG024-2. This makes it relevant to studies of viral entry as well as to work on chemotaxis and receptor signalling.
CMKLR1 is involved in positive regulation of macrophage chemotaxis, making it a focus for studies of immune cell migration.
The receptor takes part in the regulation of calcium-mediated signalling, relevant to work on how membrane receptors transduce extracellular cues.
As a member of the chemerin receptors gene group, CMKLR1 is used to study chemerin-responsive pathways and chemokine-like receptor function.
CMKLR1 acts as a coreceptor for several SIV strains and a primary HIV-1 strain, supporting research into viral entry.
CMKLR1 is a plasma membrane receptor involved in chemotaxis, including positive regulation of macrophage chemotaxis, and in regulating calcium-mediated signalling. NCBI Gene also lists adipokinetic hormone binding and receptor activity. UniProt notes it can act as a coreceptor for certain SIV and HIV-1 strains.
CMKLR1 stands for chemerin chemokine-like receptor 1. Aliases include ChemR23, RVER1 and ERV1, and the previous HGNC name was chemokine-like receptor 1. UniProt lists the protein as Chemerin-like receptor 1. These names all refer to the same gene and protein.
Yes. Both mouse and rat have an ortholog named Cmklr1, so the receptor can be studied in standard rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a particular species.
Other chemerin pathway components, chemokine-like receptors and immune signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99788; product specifications from Assay Genie datasheets.