CXCL17
CXCL17 (C-X-C motif chemokine ligand 17) is a secreted mucosal chemokine of the intercrine alpha family that attracts immature dendritic cells and blood monocytes to the lungs. It is also known as Dcip1, UNQ473, DMC and VCC1. Browse Assay Genie's current range of CXCL17 research reagents below, or read on for the biology behind the target.
CXCL17 is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. UniProt annotates it as showing much higher chemoattractant potency on monocytes and macrophages than the 6-Cys form of CXCL17. Beyond leukocyte recruitment, the encoded protein promotes tumorigenesis through an angiogenic activity, and it shows strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa and C. albicans.
The CXCL17 gene encodes a secreted protein that belongs to the intercrine alpha (chemokine CxC) family and sits within the HGNC group of chemokine ligands. NCBI Gene reports two transcript variants for the gene, one protein-coding and the other non-protein coding. The mouse ortholog is Cxcl17, which makes the mouse a natural system for studying the CXCL17 protein in vivo.
The gene was previously listed as chemokine (C-X-C motif) ligand 17 and has also been described under the names Dcip1, UNQ473, DMC and VCC1. Its combined roles in mucosal immunity, host defence and angiogenesis make CXCL17 a useful target for researchers studying how chemokines link innate immune cell recruitment, antimicrobial responses and tumour biology. Assays for the CXCL17 protein, such as a CXCL17 ELISA kit or CXCL17 antibody, support work in each of these areas.
CXCL17 is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs, making it relevant to mucosal immune surveillance.
CXCL17 shows much higher chemoattractant potency on monocytes and macrophages than the 6-Cys form, informing studies of myeloid cell recruitment.
The encoded protein promotes tumorigenesis through an angiogenic activity, so CXCL17 is studied in cancer and blood vessel formation.
CXCL17 exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa and C. albicans.
CXCL17 is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. It also promotes tumorigenesis through an angiogenic activity and has strong antimicrobial activity against bacteria such as E. coli and S. aureus, and against C. albicans.
CXCL17 is also called Dcip1, UNQ473, DMC and VCC1, and was formerly named chemokine (C-X-C motif) ligand 17. NCBI Gene describes two transcript variants: one is protein-coding and the other is non-protein coding.
Yes, the mouse ortholog is Cxcl17. Researchers can therefore study CXCL17 biology in mouse models of mucosal immunity or tumour angiogenesis. Check the datasheet of any product for its validated reactivity.
Other CXC chemokine ligands involved in leukocyte recruitment and mucosal immunity.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UXB2; product specifications from Assay Genie datasheets.