KAT5
KAT5, also known as TIP60, is a MYST family histone acetyltransferase that acetylates histone and nonhistone proteins. It was first isolated as an HIV-1 Tat-interactive protein and is also referred to as PLIP, cPLA2, HTATIP1, ESA1 and HTATIP. Browse Assay Genie's current range of KAT5 research reagents below, or read on for the biology behind the target.
KAT5 (lysine acetyltransferase 5) is a histone acetyltransferase of the MYST (SAS/MOZ) family. Histone acetyltransferases play important roles in regulating chromatin remodelling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. KAT5 is a histone acetylase with a role in DNA repair and apoptosis, and it is thought to play an important role in signal transduction. In the context of microbial infection, KAT5 has also been reported to acetylate flavivirus NS3 protein, which modulates its RNA-binding and RNA-unwinding activities and facilitates viral replication.
The human KAT5 gene encodes the enzyme classified as EC 2.3.1.48. HGNC places it in the MYST type domain containing lysine acetyltransferases, among the Tip60/Nua4 histone acetyltransferase complex subunits, and in the MYST C2HC-type zinc finger group. UniProt records the protein in the nucleus, on chromosomes and at the centromere kinetochore, in the nucleolus, and in the cytoplasm, including the spindle pole, the cytoskeleton and the perinuclear region. Alternative splicing of the gene results in multiple transcript variants. Mouse and rat each have an ortholog named Kat5.
The protein was originally isolated as an HIV-1 Tat-interactive protein, which explains the earlier names HIV-1 Tat interactive protein, 60kDa and HTATIP. The current approved name, lysine acetyltransferase 5, reflects its place in the lysine acetyltransferase nomenclature, while TIP60 remains the most widely used alias in the literature. Researchers studying KAT5 or TIP60 typically focus on chromatin regulation, DNA repair and cell death.
KAT5 acetylates histone and nonhistone proteins, making it a focus for studies of chromatin remodelling and transcriptional regulation.
KAT5 is a histone acetylase with a role in DNA repair, relevant to work on genome maintenance in the nucleus.
KAT5 has a role in apoptosis and is thought to be important in signal transduction, supporting studies of cell fate pathways.
KAT5 acetylates flavivirus NS3 protein, altering its RNA-binding and unwinding activities and facilitating viral replication.
KAT5 is a MYST family histone acetyltransferase. It acetylates histone and nonhistone proteins, contributing to chromatin remodelling, transcription and other nuclear processes. It has a role in DNA repair and apoptosis and is thought to be important in signal transduction.
KAT5 was originally isolated as an HIV-1 Tat-interactive protein, giving the names TIP60, HTATIP and HTATIP1. Other aliases include PLIP, cPLA2 and ESA1. The approved HGNC name is lysine acetyltransferase 5, and alternative splicing produces multiple transcript variants.
Mouse and rat both have an ortholog named Kat5, so the gene is conserved in common model species; check the datasheet of any product for its validated reactivity. UniProt also notes that KAT5 acetylates flavivirus NS3 protein, facilitating viral replication.
Other MYST family lysine acetyltransferases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92993; product specifications from Assay Genie datasheets.