TESPA1
TESPA1 (thymocyte expressed, positive selection associated 1) is a protein required for the development and maturation of T-cells, with a role in late thymocyte development. It is also known as ITPRID3 and, previously, KIAA0748. Browse Assay Genie's current range of TESPA1 research reagents below, or read on for the biology behind the target.
TESPA1 is required for the development and maturation of T-cells, and its function is essential for the late stages of thymocyte development. UniProt annotation describes a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signalling pathways, possibly by acting as a scaffolding protein that promotes assembly of the LAT signalosome in thymocytes.
The protein may also contribute to the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake through the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. It is found in the cytoplasm and at the endoplasmic reticulum membrane. The mouse ortholog is Tespa1, which allows the protein to be studied in murine models of T-cell development.
The human TESPA1 gene is annotated by HGNC as thymocyte expressed, positive selection associated 1. Its aliases include ITPRID3, and it was previously designated KIAA0748. NCBI Gene summarises predicted functions from the Alliance of Genome Resources: phospholipase binding and signalling receptor binding, involvement in positive regulation of T cell differentiation in the thymus and positive regulation of the T cell receptor signalling pathway, and a role in TCR signalosome assembly. It is also predicted to be involved in COP9 signalosome assembly and to be part of the COP9 signalosome, and is located in the cytosol.
TESPA1 is essential for the late stages of thymocyte development and for T-cell maturation, making it a focus for studies of T-cell differentiation.
It contributes to TCR-mediated activation of the ERK and NFAT pathways, possibly as a scaffold for LAT signalosome assembly.
TESPA1 may regulate IP3 receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake at the MAM compartment.
Predicted involvement in TCR and COP9 signalosome assembly makes TESPA1 relevant to studies of multiprotein signalling complexes.
TESPA1 is required for T-cell development and maturation, particularly the late stages of thymocyte development. It supports TCR-mediated activation of the ERK and NFAT pathways, possibly as a scaffold promoting LAT signalosome assembly, and may influence IP3 receptor-mediated Ca(2+) release.
The HGNC full name is thymocyte expressed, positive selection associated 1, and UniProt lists Protein TESPA1. Aliases include ITPRID3, and the gene was previously known as KIAA0748. These names refer to the same human gene and protein.
Yes. The mouse ortholog is named Tespa1, which supports study of the protein's role in T-cell development in murine systems. No rat ortholog is given in the source data. Check the datasheet of any product for its validated reactivity.
Other T-cell receptor signalling proteins, calcium-release channels and ERK and NFAT pathway components with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A2RU30; product specifications from Assay Genie datasheets.