VDAC1
VDAC1 (voltage dependent anion channel 1, also known as PORIN) is a major component of the outer mitochondrial membrane. It facilitates the exchange of metabolites and ions across that membrane and may regulate mitochondrial functions. Browse Assay Genie's current range of VDAC1 research reagents below, or read on for the biology behind the target.
VDAC1 is a non-selective voltage-gated ion channel that sits in the outer mitochondrial membrane, where it facilitates the exchange of metabolites and ions between the mitochondrion and the rest of the cell. Through this role it may regulate mitochondrial functions. UniProt also annotates a distinct activity: VDAC1 catalyses the scrambling of phospholipids across the outer mitochondrial membrane. This mechanism is unrelated to channel activity and can translocate both anionic and zwitterionic phospholipids.
Besides the mitochondrial outer membrane, VDAC1 is annotated at the cell membrane and in membrane rafts. NCBI Gene notes that the protein forms channels in the plasma membrane and may be involved in transmembrane electron transport. The protein belongs to the eukaryotic mitochondrial porin family, and the HGNC places the VDAC1 gene in the group of voltage dependent anion channels. Alternate splicing of the gene results in multiple transcript variants, and multiple pseudogenes are found on chromosomes 1, 2, 3, 6, 9, 12, X and Y.
The official name is voltage dependent anion channel 1. Earlier or alternative names include PORIN and MGC111064, and the UniProt recommended name is non-selective voltage-gated ion channel VDAC1. Mouse and rat both carry a Vdac1 ortholog, so the protein can be studied in common rodent models as well as in human systems. Researchers working on the VDAC1 protein often use it as a reference marker for the outer mitochondrial membrane.
VDAC1 is a major outer mitochondrial membrane component that facilitates metabolite and ion exchange, making it central to studies of mitochondrial function.
UniProt annotates VDAC1 as a phospholipid scramblase of the outer mitochondrial membrane, independent of channel activity, relevant to lipid translocation research.
VDAC1 forms channels in the plasma membrane and may take part in transmembrane electron transport, so it is studied beyond the mitochondrion.
VDAC1 is annotated in membrane rafts as well as the cell membrane, which supports work on its distribution across cellular compartments.
VDAC1 is a voltage-gated anion channel in the outer mitochondrial membrane. It facilitates the exchange of metabolites and ions across that membrane and may regulate mitochondrial functions. UniProt also describes a separate phospholipid scrambling activity that is unrelated to its channel function.
The HGNC name is voltage dependent anion channel 1. Aliases include PORIN and MGC111064, and UniProt lists the protein as non-selective voltage-gated ion channel VDAC1. NCBI Gene reports that alternate splicing produces multiple transcript variants.
Yes. Mouse and rat each have an ortholog named Vdac1, and the protein belongs to the eukaryotic mitochondrial porin family. Check the datasheet of any product for its validated reactivity.
Other voltage dependent anion channels and mitochondrial membrane proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P21796; product specifications from Assay Genie datasheets.