DISC1
DISC1 (DISC1 scaffold protein, formerly disrupted in schizophrenia 1) is a multi-domain coiled-coil protein that regulates neurogenesis, neurite outgrowth and cortical development. It belongs to the HGNC group of centriolar satellite proteins. Browse Assay Genie's current range of DISC1 research reagents below, or read on for the biology behind the target.
DISC1 acts in several aspects of embryonic and adult neurogenesis. It is required for neural progenitor proliferation in the ventricular/subventricular zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. In Wnt-mediated progenitor proliferation it acts as a positive regulator, modulating GSK3B activity and CTNNB1 abundance.
The protein also modulates AKT-mTOR signalling, controlling the tempo at which newborn neurons integrate during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Through its interaction with CCDC88A, DISC1 inhibits activation of AKT-mTOR signalling. It regulates the migration of early-born granule cell precursors towards the dentate gyrus during hippocampal development, and inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerisation and DNA binding. Together with PCNT, it contributes to microtubule network formation.
The DISC1 gene encodes a protein with multiple coiled-coil motifs, found in the nucleus, cytoplasm and mitochondria; UniProt additionally records the centrosome and postsynaptic density. The gene takes its name from a t(1;11)(q42.1;q14.3) translocation that segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternative splice variants encoding different isoforms have been characterised. Mouse and rat orthologs are both designated Disc1, which supports work in rodent models of neurodevelopment.
DISC1 regulates neural progenitor proliferation and the integration of newborn neurons in the adult hippocampal dentate gyrus.
The protein contributes to embryonic brain development, neurite outgrowth and migration of granule cell precursors towards the dentate gyrus.
The gene is disrupted by a translocation that segregates with schizophrenia and related psychiatric disorders in a Scottish family.
DISC1 modulates GSK3B activity, CTNNB1 abundance and AKT-mTOR signalling, linking a scaffold protein to neuronal pathway control.
DISC1 is a scaffold protein that regulates embryonic and adult neurogenesis. It supports neural progenitor proliferation, modulates Wnt and AKT-mTOR signalling, guides granule cell precursor migration, inhibits ATF4 activity in neurons and works with PCNT in microtubule network formation.
The name reflects a t(1;11)(q42.1;q14.3) translocation that disrupts the gene and segregates with schizophrenia and related psychiatric disorders in a large Scottish family. HGNC now lists the approved name as DISC1 scaffold protein, with the former name retained as a previous name. Alternative splice variants encode different isoforms.
Yes. Mouse and rat both have an ortholog named Disc1, so the human DISC1 gene can be studied in rodent neurodevelopment models. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Signalling partners, centrosomal proteins and neurogenesis-related targets linked to DISC1 function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NRI5; product specifications from Assay Genie datasheets.