FTMT
FTMT (ferritin mitochondrial, also known as MtF) is a member of the ferritin family that catalyses the oxidation of ferrous iron and stores the resulting iron in a soluble, non-toxic form. It is located in the mitochondrion and contributes to iron homeostasis. Browse Assay Genie's current range of FTMT research reagents below, or read on for the biology behind the target.
FTMT is a ferroxidase that catalyses the oxidation of iron(II) to iron(III). Iron is taken up in the ferrous form and, after oxidation, is deposited as ferric hydroxides. This lets the protein hold iron in a soluble, non-toxic and readily available form, and it is described as important for iron homeostasis. Because it acts inside the mitochondrion, FTMT is a useful focus for studies of how iron is handled in that compartment.
The FTMT gene encodes the protein Ferritin, mitochondrial, which belongs to the ferritin family. In HGNC it is classified within the ferritin chains and ferritin ferroxidases gene groups, and the enzyme carries the EC number 1.16.3.1. The mouse ortholog is Ftmt. Researchers working with the FTMT gene or FTMT protein will often be interested in its ferroxidase and iron-binding activities.
NCBI Gene summarises the protein as enabling ferroxidase activity and iron ion binding activity, and as being involved in intracellular iron ion homeostasis and protein maturation. It is located in the mitochondrion. The alias MtF is used in the literature for mitochondrial ferritin, which distinguishes it from the cytosolic ferritin chains that also belong to the ferritin family.
FTMT is important for iron homeostasis and acts within the mitochondrion, making it a relevant target for studying intracellular iron handling.
FTMT catalyses the oxidation of ferrous iron(II) to ferric iron(III), so it is studied as a ferroxidase of the ferritin family.
The protein deposits iron as ferric hydroxides, holding it in a soluble, non-toxic and readily available form.
As a mitochondrial member of the ferritin chains and ferroxidases gene groups, FTMT supports comparison with other ferritin family proteins.
FTMT catalyses the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Iron is taken up as ferrous iron and deposited as ferric hydroxides. The protein is important for iron homeostasis and is located in the mitochondrion.
The HGNC symbol is FTMT, the approved name is ferritin mitochondrial, and the UniProt protein name is Ferritin, mitochondrial. MtF is a recognised alias. HGNC lists no previous names. The enzyme has the EC number 1.16.3.1, reflecting its ferroxidase activity.
A mouse ortholog, Ftmt, is recorded for the human gene. FTMT belongs to the ferritin family, whose members share iron-handling roles. No rat ortholog is given in the data used here, so check the datasheet of any product for its validated reactivity.
Other ferritin chains, ferroxidases and iron-metabolism proteins that may be of interest alongside FTMT.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N4E7; product specifications from Assay Genie datasheets.