DPP6
DPP6 (dipeptidyl peptidase like 6, also known as DPPX or DPL1) is a single-pass type II membrane protein of the peptidase S9B family. It promotes cell surface expression of the potassium channel KCND2 and modulates its gating, without having dipeptidyl aminopeptidase activity. Browse Assay Genie's current range of DPP6 research reagents below, or read on for the biology behind the target.
DPP6 acts as an auxiliary regulator of voltage-gated potassium channels. According to UniProt, it promotes cell surface expression of the potassium channel KCND2 and modulates the activity and gating characteristics of that channel. This is why the protein is listed by UniProt as the A-type potassium channel modulatory protein DPP6, and why HGNC places it in the group of potassium voltage-gated channel regulatory subunits.
The DPP6 gene encodes a single-pass type II membrane protein that localises to the cell membrane. It belongs to the peptidase S9B family of serine proteases and to the DASH family. Despite this classification, the DPP6 protein has no detectable protease activity, most likely because it lacks the conserved serine residue normally present in the catalytic domain of serine proteases. It does, however, bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternative splicing of the gene results in multiple transcript variants. Mouse and rat orthologs are both designated Dpp6.
The protein was first named for its similarity to dipeptidyl peptidases, and earlier names include dipeptidylpeptidase VI and dipeptidyl peptidase 6, alongside the aliases DPPX and DPL1. Variations in the gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Researchers studying channel regulation often consider DPP6 together with related family members such as DPP10 and the active peptidase DPP4.
DPP6 promotes cell surface expression of KCND2 and modulates its gating, making it a model for studying auxiliary subunits of voltage-gated potassium channels.
As a type II membrane protein that raises channel levels at the cell surface, DPP6 is relevant to studies of how channel expression is controlled.
Variations in the DPP6 gene may be associated with susceptibility to amyotrophic lateral sclerosis, prompting genetic and functional investigation.
Variations in DPP6 may be associated with idiopathic ventricular fibrillation, linking the protein to research on electrical excitability and rhythm disorders.
DPP6 promotes cell surface expression of the potassium channel KCND2 and modulates its activity and gating characteristics. It binds specific voltage-gated potassium channels and alters their expression and biophysical properties, but it has no dipeptidyl aminopeptidase activity.
DPP6 is also known as DPPX and DPL1, and earlier names include dipeptidylpeptidase VI and dipeptidyl peptidase 6. UniProt calls it the A-type potassium channel modulatory protein DPP6. Alternative splicing of the gene produces multiple transcript variants.
Although DPP6 belongs to the peptidase S9B family, it has no detectable protease activity, most likely because the conserved catalytic serine is absent. Variations in the gene may be associated with susceptibility to amyotrophic lateral sclerosis and idiopathic ventricular fibrillation. Mouse and rat orthologs are named Dpp6.
Other dipeptidyl peptidase family members and related proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P42658; product specifications from Assay Genie datasheets.