ANXA4
ANXA4 (annexin A4, also known as ANX4 or annexin IV) is a calcium- and phospholipid-binding protein of the annexin family. It promotes membrane fusion and is involved in exocytosis. Browse Assay Genie's current range of ANXA4 research reagents below, or read on for the biology behind the target.
ANXA4 is a calcium- and phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. It belongs to the annexin family of calcium-dependent phospholipid-binding proteins. Although the precise functions of the family are still not clearly defined, several members have been implicated in membrane-related events along exocytotic and endocytotic pathways. In UniProt, the ANXA4 protein is assigned to the zymogen granule membrane.
The ANXA4 gene is classed by HGNC in the Annexins gene group. The encoded protein shares 45 to 59% identity with other annexin family members, along with a similar size and exon-intron organisation. According to the NCBI Gene summary, ANXA4 is almost exclusively expressed in epithelial cells, which makes it a relevant marker when studying epithelial biology. Several transcript variants encoding different isoforms have been reported for the gene.
ANXA4 was isolated from human placenta, where it was described as annexin IV, and the older symbol ANX4 is still widely used. The protein has possible interactions with ATP. In vitro, it shows anticoagulant activity and inhibits phospholipase A2 activity. Mouse and rat each carry an Anxa4 ortholog, so the target can be studied in common rodent models. Researchers looking for an ANXA4 antibody, ANXA4 ELISA kit or recombinant ANXA4 protein will often be investigating membrane trafficking, exocytosis or epithelial cell function.
ANXA4 promotes membrane fusion and is involved in exocytosis, making it a useful subject for studies of secretory vesicle behaviour.
ANXA4 shares 45 to 59% identity with other annexins, supporting comparative work on calcium-dependent phospholipid-binding proteins.
ANXA4 is almost exclusively expressed in epithelial cells, so it is relevant to research on epithelial-specific protein function.
In vitro, ANXA4 shows anticoagulant activity and inhibits phospholipase A2 activity, prompting study of phospholipid-related processes.
ANXA4 is a calcium- and phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. Annexin family members are implicated in membrane events along exocytotic and endocytotic pathways, although their functions are not yet clearly defined.
ANXA4 is also known as ANX4 and annexin IV. The NCBI Gene summary notes that several transcript variants encoding different isoforms have been found for this gene, so check which isoform a given reagent is intended to detect.
Mouse and rat both have an Anxa4 ortholog. Within the human annexin family, ANXA4 shares 45 to 59% identity with other members and is almost exclusively expressed in epithelial cells. Check the datasheet of any product for its validated reactivity.
Other annexin family members with related calcium-dependent phospholipid-binding functions.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09525; product specifications from Assay Genie datasheets.