GDF1
GDF1 (growth differentiation factor 1) is a secreted ligand of the TGF-beta superfamily that may mediate cell differentiation events during embryonic development. The GDF1 gene encodes a preproprotein that is processed into a disulfide-linked homodimer. Browse Assay Genie's current range of GDF1 research reagents below, or read on for the biology behind the target.
GDF1 is a secreted signalling ligand that belongs to the TGF-beta (transforming growth factor-beta) superfamily. Ligands of this family bind various TGF-beta receptors, which leads to recruitment and activation of SMAD family transcription factors that in turn regulate gene expression. UniProt annotates the protein as one that may mediate cell differentiation events during embryonic development.
The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which is the mature secreted form of the GDF1 protein. An unusual feature of the GDF1 gene is that the protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1, so the two products share a transcript.
Studies in rodents suggest that GDF1 is involved in establishing left-right asymmetry in early embryogenesis and in neural development later in embryogenesis. In humans, mutations in the gene are associated with several congenital cardiovascular malformations, which makes it a relevant target for developmental and cardiac research. The mouse ortholog is Gdf1. HGNC classifies the gene within the transforming growth factor beta superfamily, alongside other growth differentiation factors such as GDF-3, GDF-5 and GDF-11.
GDF1 may mediate cell differentiation events during embryogenesis, making it a focus for studies of early developmental signalling.
Rodent studies suggest GDF1 helps establish left-right asymmetry in early embryos, a key question in body-plan research.
Mutations in GDF1 are associated with several congenital cardiovascular malformations, supporting its study in cardiac development and disease.
As a TGF-beta superfamily ligand acting through receptors and SMAD transcription factors, GDF1 is relevant to gene regulation studies.
GDF1 is a secreted TGF-beta superfamily ligand that may mediate cell differentiation events during embryonic development. Family ligands bind TGF-beta receptors, activating SMAD transcription factors that regulate gene expression. Rodent studies link it to left-right asymmetry and neural development.
Yes, at the level of the transcript. GDF1 is translated from a bicistronic mRNA that also encodes ceramide synthase 1. The GDF1 preproprotein is then proteolytically processed to give the subunits of a disulfide-linked homodimer, which is secreted.
Mutations in GDF1 are associated with several congenital cardiovascular malformations. The mouse ortholog is Gdf1, and rodent studies have informed understanding of its roles in embryogenesis. Check the datasheet of any product for its validated reactivity.
Other growth differentiation factors and TGF-beta superfamily ligands with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P27539; product specifications from Assay Genie datasheets.