SNRPN
SNRPN (small nuclear ribonucleoprotein polypeptide N) is a nuclear component of the small nuclear ribonucleoprotein complex that functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. It is also known as SMN, SM-D, HCERN3, SNRNP-N, SNURF-SNRPN, RT-LI and PWCR. Browse Assay Genie's current range of SNRPN research reagents below, or read on for the biology behind the target.
SNRPN encodes a component of the small nuclear ribonucleoprotein (snRNP) complex, which functions in pre-mRNA processing. UniProt annotates the protein as possibly involved in tissue-specific alternative RNA processing events, and the NCBI Gene summary similarly notes that it may contribute to tissue-specific alternative splicing. The protein localises to the nucleus.
The SNRPN protein belongs to the snRNP SmB/SmN family and is classified by HGNC within the Sm spliceosomal proteins gene group. The SNRPN gene lies on chromosome 15q11.2, within the Prader-Willi syndrome critical region, and is imprinted, being expressed from the paternal allele. Mouse and rat both carry an orthologous Snrpn gene. Researchers studying the SNRPN protein, whether by SNRPN antibody-based detection or other approaches, are often interested in its role in splicing regulation and in imprinting.
The locus is complex. Alternative promoter use and alternative splicing produce many transcript variants that encode the same protein. Variants that start at the CpG island-associated imprinting centre may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. Long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from promoters at this locus and share exons with the SNRPN gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. The gene was previously named for the Prader-Willi syndrome chromosome region (PWCR).
SNRPN is an snRNP component that may contribute to tissue-specific alternative splicing, making it relevant to studies of pre-mRNA processing.
The gene is imprinted and expressed from the paternal allele, with an imprinting centre at its promoter region.
SNRPN lies within the Prader-Willi syndrome critical region on chromosome 15, and alterations there are linked to the disorder.
Parental imprint switch failure at this locus may cause Angelman syndrome or Prader-Willi syndrome, so SNRPN is a focus for imprinting disorder work.
SNRPN is a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing. UniProt states it may be involved in tissue-specific alternative RNA processing events, and the NCBI Gene summary says it may contribute to tissue-specific alternative splicing. It localises to the nucleus.
SNRPN is also called SMN, SM-D, HCERN3, SNRNP-N, SNURF-SNRPN, RT-LI and PWCR, and was previously named for the Prader-Willi syndrome chromosome region. Transcripts can be bicistronic and also encode SNURF from an upstream open reading frame. Many transcript variants encode the same SNRPN protein.
SNRPN sits in the Prader-Willi syndrome critical region on chromosome 15 and is expressed from the paternal allele. Alterations there are associated with imprint switch failure, which may cause Angelman or Prader-Willi syndrome. Mouse and rat have Snrpn orthologues; check the datasheet of any product for its validated reactivity.
Other Sm spliceosomal proteins and genes sharing the SNRPN imprinted locus, relevant to splicing and imprinting research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P63162; product specifications from Assay Genie datasheets.