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RGS22
RGS22 (regulator of G protein signalling 22) is a member of the regulators of G-protein signalling group. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, and is also known as DKFZP434I092, PRTD-NY2 and CT145. Browse Assay Genie's current range of RGS22 research reagents below, or read on for the biology behind the target.
RGS22 acts as a brake on G protein signalling. According to UniProt, it inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, which drives them into their inactive GDP-bound form. NCBI Gene describes the protein as enabling G-protein alpha-subunit binding activity and as predicted to be involved in the negative regulation of signal transduction. Studies of the RGS22 protein therefore sit within the wider question of how G protein signals are switched off after receptor activation.
The RGS22 gene encodes a large protein that UniProt places in the cytoplasm and the nucleus. NCBI Gene reports it in the cytosol and the fibrillar centre. The mouse counterpart is named Rgs22, which allows comparative work between human and mouse systems. Researchers who plan an RGS22 antibody or RGS22 ELISA kit experiment should consider these localisation data when they choose sample preparation and readouts.
HGNC classifies the gene in two groups: the regulators of G-protein signalling and the microRNA protein coding host genes. Besides the approved symbol, the gene has appeared under the aliases DKFZP434I092, PRTD-NY2 and CT145. Earlier HGNC names spelled the full name as regulator of G-protein signalling 22 or regulator of G-protein signalling 22. These variants are worth searching when you review older literature and database records.
RGS22 increases the GTPase activity of G protein alpha subunits, so it is relevant to studies of how G protein signals are terminated.
NCBI Gene predicts a role for RGS22 in the negative regulation of signal transduction, which makes it a candidate for pathway-level studies.
UniProt reports RGS22 in the cytoplasm and nucleus, and NCBI Gene in the cytosol and fibrillar centre, which supports localisation work.
As a member of the regulators of G-protein signalling gene group, RGS22 can be compared with other RGS proteins in studies of GTPase regulation.
RGS22 inhibits signal transduction. It increases the GTPase activity of G protein alpha subunits, which drives them into their inactive GDP-bound form. NCBI Gene also lists G-protein alpha-subunit binding activity and predicts a role in the negative regulation of signal transduction.
The HGNC full name is regulator of G protein signalling 22. Aliases and previous symbols include DKFZP434I092, PRTD-NY2 and CT145. Earlier names used the spelling regulator of G-protein signalling 22. Searching all of these terms helps when you check older publications and database entries.
The mouse ortholog is Rgs22. HGNC places the human gene in the regulators of G-protein signalling group and in the microRNA protein coding host genes group. Check the datasheet of any product for its validated reactivity.
Other regulators of G-protein signalling that share the GTPase-accelerating function of RGS22, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NE09; product specifications from Assay Genie datasheets.
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