DPYSL3
DPYSL3 (dihydropyrimidinase like 3) is a cytoplasmic protein needed for class 3 semaphorin signalling and the cytoskeletal remodelling that follows. It is also known as DRP-3, ULIP and CRMP4, and it contributes to axon guidance, growth cone collapse and cell migration. Browse Assay Genie's current range of DPYSL3 research reagents below, or read on for the biology behind the target.
DPYSL3 is necessary for signalling by class 3 semaphorins and for the subsequent remodelling of the cytoskeleton. Through this role the DPYSL3 protein takes part in axon guidance, neuronal growth cone collapse and cell migration, linking extracellular guidance cues to changes in cell shape and movement.
The DPYSL3 gene encodes dihydropyrimidinase-related protein 3, which is found in the cytoplasm and in the growth cone, a cell projection at the tip of extending neurites. NCBI Gene annotation reports that it enables filamin binding. It is predicted to be involved in actin filament organisation, regulation of plasma membrane bounded cell projection organisation and response to axon injury, and to act upstream of or within nervous system development. It is also predicted to be located in the lamellipodium and exocytic vesicles, to be part of filamentous actin and to be active in the cytosol.
DPYSL3 belongs to the metallo-dependent hydrolases superfamily and the hydantoinase/dihydropyrimidinase family; HGNC places it in the M38 metallopeptidases gene group. Its aliases include DRP-3, ULIP and CRMP4, and its previous name was dihydropyrimidinase-like 3. The family also includes DPYSL2 and DPYSL4. Orthologues are annotated in mouse and rat as Dpysl3, which allows the pathway to be studied in common model systems.
DPYSL3 is implicated in axon guidance and neuronal growth cone collapse, making it a relevant target for studies of how neurites find their paths.
DPYSL3 is necessary for class 3 semaphorin signalling, so it is useful for dissecting how guidance cues are converted into cytoskeletal responses.
DPYSL3 contributes to cytoskeletal remodelling and cell migration, and is predicted to associate with filamentous actin and the lamellipodium.
Predicted roles in nervous system development and response to axon injury make DPYSL3 a candidate for work on neural development and repair.
DPYSL3 is necessary for signalling by class 3 semaphorins and the cytoskeletal remodelling that follows. It plays a role in axon guidance, neuronal growth cone collapse and cell migration. It is located in the cytoplasm and in growth cones, and enables filamin binding.
DPYSL3 is the HGNC symbol for dihydropyrimidinase like 3. The protein is called dihydropyrimidinase-related protein 3 in UniProt, and aliases include DRP-3, ULIP and CRMP4. The previous name was dihydropyrimidinase-like 3, so literature may use any of these terms.
Mouse and rat both carry a Dpysl3 orthologue. DPYSL3 belongs to the hydantoinase/dihydropyrimidinase family within the metallo-dependent hydrolases superfamily, but no EC number is assigned, and its characterised role is in semaphorin signalling and cytoskeletal remodelling. Check the datasheet of any product for its validated reactivity.
Other dihydropyrimidinase-like family members involved in neuronal development and cytoskeletal signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14195; product specifications from Assay Genie datasheets.