CAPZB
CAPZB (capping actin protein of muscle Z-line subunit beta) is the beta subunit of the heterodimeric F-actin capping protein. It binds the barbed ends of actin filaments, regulating filament dynamics and cytoskeletal organisation in muscle and nonmuscle cells. Browse Assay Genie's current range of CAPZB research reagents below, or read on for the biology behind the target.
CAPZB is the beta subunit of the F-actin capping protein, a heterodimer that binds the fast-growing (barbed) ends of actin filaments. By occupying these ends it blocks the exchange of subunits, so that filament assembly and disassembly are both prevented at the barbed end. This binding is independent of Ca(2+). Unlike other capping proteins such as gelsolin and severin, the F-actin-capping proteins do not sever actin filaments.
Through this activity CAPZB helps regulate actin filament dynamics and stabilise filament lengths in muscle and nonmuscle cells, and it contributes to the control of cell morphology and cytoskeletal organisation. UniProt records the protein in the cytoskeleton and in the sarcomere of the myofibril. It belongs to the F-actin-capping protein beta subunit family.
CAPZB also has a role beyond the actin cortex. Together with its partner capping subunit, it forms the barbed end of the short actin-like filament in the dynactin complex and stabilises dynactin structure. The dynactin multiprotein complex activates the motor dynein for ultra-processive transport along microtubules, and HGNC accordingly classifies the CAPZB gene within the dynactin subunits group. The earlier names, capping protein (actin filament) muscle Z-line, beta, reflect its initial characterisation in muscle. According to NCBI Gene, a pseudogene lies on the long arm of chromosome 2, and the gene produces multiple alternatively spliced transcript variants that encode different isoforms.
CAPZB blocks assembly and disassembly at barbed ends, making it a key subject for studies of actin filament dynamics and length control.
The protein stabilises actin filament lengths in muscle cells and localises to the sarcomere, linking it to myofibril organisation.
As part of the dynactin complex, CAPZB stabilises its structure, supporting research on dynein activation and microtubule-based transport.
Capping of actin filament ends contributes to the regulation of cell morphology and cytoskeletal organisation in muscle and nonmuscle cells.
CAPZB is the beta subunit of the F-actin capping protein. It binds the barbed ends of actin filaments in a Ca(2+)-independent manner, blocking subunit exchange without severing filaments, and so regulates actin dynamics, filament length and cell morphology. It also stabilises the dynactin complex.
The full name is capping actin protein of muscle Z-line subunit beta; UniProt calls it F-actin-capping protein subunit beta. Earlier HGNC names include capping protein (actin filament) muscle Z-line, beta. NCBI Gene reports multiple alternatively spliced transcript variants encoding different isoforms.
Yes. Orthologues are annotated in mouse and rat, both named Capzb. The human gene is in the dynactin subunits gene group. Check the datasheet of any product for its validated reactivity.
Other actin-capping proteins, dynactin subunits and cytoskeletal proteins related to CAPZB.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P47756; product specifications from Assay Genie datasheets.