WNT2B
WNT2B (Wnt family member 2B, also known as WNT13 and XWNT2) is a secreted signalling ligand of the Wnt family. It binds frizzled receptors and acts in the canonical Wnt/beta-catenin pathway. Browse Assay Genie's current range of WNT2B research reagents below, or read on for the biology behind the target.
WNT2B is a ligand for members of the frizzled family of seven transmembrane receptors. It functions in the canonical Wnt/beta-catenin signalling pathway, in which extracellular Wnt ligands engage frizzled receptors to control cellular responses. UniProt annotates a redundant role for WNT2B in embryonic lung development, meaning that other factors can compensate for it in that context.
The WNT2B gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signalling factors. The protein is found in the extracellular space and extracellular matrix. As with other WNT family members, it is characterised by a WNT-core domain, and WNT proteins as a group take part in a variety of developmental processes, including the regulation of cell growth and differentiation. Alternative splicing of the gene results in multiple transcript variants. The mouse ortholog is Wnt2b.
The gene has carried several names. Its previous HGNC name was wingless-type MMTV integration site family, member 2B, and it has also been listed as WNT13 and XWNT2. According to the NCBI Gene summary, WNT2B may play a role in human development as well as in carcinogenesis, which makes it a relevant target for researchers studying developmental signalling and Wnt pathway activity. Researchers working on the WNT2B protein, whether as a recombinant ligand or an endogenous secreted factor, can use these functional details to plan pathway-focused experiments.
WNT2B acts as a frizzled ligand in the canonical Wnt/beta-catenin pathway, making it a useful target for dissecting ligand-driven pathway activation.
UniProt records a redundant role for WNT2B in embryonic lung development, relevant to studies of developmental signalling and compensation among Wnt ligands.
WNT family members regulate cell growth and differentiation, and WNT2B is studied as part of this developmental signalling network.
The NCBI Gene summary suggests WNT2B may play a role in carcinogenesis as well as human development, supporting its study in cancer biology.
WNT2B is a secreted ligand for frizzled family seven transmembrane receptors and functions in the canonical Wnt/beta-catenin signalling pathway. It plays a redundant role in embryonic lung development. More broadly, WNT family members regulate cell growth and differentiation during development.
WNT2B is also known as WNT13 and XWNT2. Its earlier HGNC name was wingless-type MMTV integration site family, member 2B, and UniProt calls the protein Protein Wnt-2b. Alternative splicing of the gene produces multiple transcript variants, so check the datasheet of any product for its validated reactivity.
WNT2B belongs to the highly conserved Wnt family, and a mouse ortholog, Wnt2b, is recognised. The NCBI Gene summary notes that WNT2B may play a role in human development as well as carcinogenesis, although the source text does not specify particular diseases.
Other Wnt family ligands that signal through frizzled receptors and the Wnt/beta-catenin pathway.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q93097; product specifications from Assay Genie datasheets.