CYB561
CYB561 (cytochrome b561) is a transmembrane ascorbate-dependent reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) to Fe(2+). It is also known as FRRS2, CYB561A1 and CGCytb. Browse Assay Genie's current range of CYB561 research reagents below, or read on for the biology behind the target.
CYB561 is a transmembrane reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) into Fe(2+), and it could play a role in iron transport. It is also able to reduce extracellular monodehydro-L-ascorbate. In this way it could be involved in the regeneration and homeostasis of ascorbate within secretory vesicles, which in turn provides the reducing equivalents needed to support the activity of intravesicular enzymes.
The protein is annotated in UniProt as located in the membrane of secretory vesicles, specifically the chromaffin granule membrane, within the cytoplasmic vesicle compartment. NCBI Gene summarises the human CYB561 gene as predicted to enable transmembrane monodehydroascorbate reductase activity and to be involved in ascorbate homeostasis. It is also predicted to be active in the lysosomal membrane. These assignments are predictions from the Alliance of Genome Resources rather than experimentally confirmed in every case.
HGNC places the gene in the cytochrome b561 gene group, and the enzyme carries the EC number 7.2.1.3. Alternative names found in the literature and databases include FRRS2, CYB561A1 and CGCytb. The mouse ortholog is named Cyb561, which allows the function of this protein to be studied in murine systems. Researchers working on vesicular redox biology, ascorbate recycling and iron handling study the CYB561 protein and gene in this context.
CYB561 may regenerate ascorbate inside secretory vesicles, supplying reducing equivalents for intravesicular enzymes.
The protein reduces extracellular monodehydro-L-ascorbate and is predicted to contribute to ascorbate homeostasis.
By probably reducing Fe(3+) to Fe(2+) with ascorbate as donor, CYB561 could play a role in iron transport.
CYB561 is found in the chromaffin granule membrane, making it relevant to the biology of secretory vesicles.
CYB561 is a transmembrane reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) into Fe(2+) and could play a role in iron transport. It can also reduce extracellular monodehydro-L-ascorbate, which may help maintain ascorbate within secretory vesicles.
The HGNC symbol is CYB561 for cytochrome b561. Aliases include FRRS2, CYB561A1 and CGCytb, and UniProt names the protein transmembrane ascorbate-dependent reductase CYB561. It belongs to the HGNC cytochrome b561 gene group and has the EC number 7.2.1.3.
Yes. The mouse ortholog is named Cyb561, so the gene can be studied in mouse models. Cross-reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other cytochrome and cytochrome-reductase targets involved in electron transfer and redox biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49447; product specifications from Assay Genie datasheets.