IGSF1
IGSF1 (immunoglobulin superfamily member 1) is a membrane-associated and secreted member of the immunoglobulin-like domain-containing superfamily. It appears to act as a coreceptor in inhibin signalling and is also known as INHBP, IGDC1, IGCD1, KIAA0364 and PGSF2. Browse Assay Genie's current range of IGSF1 research reagents below, or read on for the biology behind the target.
IGSF1 appears to function as a coreceptor in inhibin signalling, although it does not seem to be a high-affinity inhibin receptor. It antagonises activin A signalling, whether or not inhibin B is present. It is also necessary to mediate the specific antagonistic effect of inhibin B on activin-stimulated transcription, which places the IGSF1 protein at a point where inhibin and activin signals are balanced.
The IGSF1 gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. UniProt lists the protein as both membrane-associated and secreted, and multiple transcript variants encoding different isoforms have been reported for the gene. The mouse and rat orthologs are both named Igsf1.
HGNC classifies immunoglobulin superfamily member 1 in the group of immunoglobulin like domain containing genes. The gene has carried several other symbols and names over time, including INHBP, IGDC1, IGCD1, KIAA0364, MGC75490 and PGSF2, and it was previously named immunoglobulin superfamily, member 1. Researchers working on inhibin, activin and related transforming growth factor-beta family signalling often study IGSF1 to understand how these pathways are modulated at the cell surface.
IGSF1 helps mediate the antagonistic effect of inhibin B on activin-stimulated transcription, making it relevant to studies of how these related ligands are balanced.
IGSF1 appears to act as a coreceptor rather than a high-affinity inhibin receptor, which makes it useful for examining how receptor complexes are assembled.
IGSF1 antagonises activin A signalling in the presence or absence of inhibin B, so it is studied in work on activin-responsive transcription.
As an immunoglobulin superfamily member, IGSF1 belongs to a protein group thought to regulate interactions between cells.
IGSF1 seems to be a coreceptor in inhibin signalling, though not a high-affinity inhibin receptor. It antagonises activin A signalling with or without inhibin B, and it is necessary for the antagonistic effect of inhibin B on activin-stimulated transcription.
IGSF1 is also known as INHBP, IGDC1, IGCD1, KIAA0364, MGC75490 and PGSF2. Its full name is immunoglobulin superfamily member 1. NCBI Gene reports multiple transcript variants that encode different isoforms of the protein.
Yes. Orthologs named Igsf1 are annotated in both mouse and rat, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other immunoglobulin superfamily members with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N6C5; product specifications from Assay Genie datasheets.