TRPM7
TRPM7 (transient receptor potential cation channel subfamily M member 7, also known as CHAK1, LTRPC7 and TRP-PLIK) is a dual-function protein that acts as both an ion channel and a serine/threonine protein kinase. It contributes to calcium signalling and magnesium ion homeostasis. Browse Assay Genie's current range of TRPM7 research reagents below, or read on for the biology behind the target.
TRPM7 belongs to the melastatin subfamily of transient receptor potential ion channels, and it is unusual in combining two activities in one polypeptide. The protein is an ion channel and a serine/threonine protein kinase, and its kinase activity is essential for channel function. The channel serves to increase intracellular calcium levels and helps regulate magnesium ion homeostasis. The encoded protein is also involved in cytoskeletal organisation, cell adhesion, cell migration and organogenesis.
The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, caspases clip the TRPM7 kinase domain from the channel domain in response to Fas-receptor stimulation. The released kinase fragments can translocate to the nucleus and bind chromatin-remodelling complex proteins in a Zn(2+)-dependent manner. There they phosphorylate specific Ser/Thr residues of histones that are functionally important for cell differentiation and embryonic development. Reflecting these roles, the protein is found at the cell membrane, in cytoplasmic vesicle membranes and in the nucleus.
In UniProt, the protein belongs to the transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM7 sub-subfamily. HGNC places the TRPM7 gene in both the alpha kinase group and the TRPM channel group. Earlier names include CHAK1, LTRPC7 and TRP-PLIK. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam, and the gene may also be associated with defects of cardiac function. Mouse and rat both carry a Trpm7 ortholog.
TRPM7 helps regulate magnesium ion homeostasis and raises intracellular calcium, making it a focus for studies of divalent cation handling.
The protein is involved in cytoskeletal organisation, cell adhesion and cell migration, so it is studied in cell motility.
The cleaved kinase fragment can reach the nucleus and phosphorylate histones important for cell differentiation and embryonic development.
Defects in the gene are linked to Guam ALS-parkinsonism/dementia complex, and it may be associated with defects of cardiac function.
TRPM7 is both an ion channel and a serine/threonine protein kinase. Its kinase activity is essential for channel function, which increases intracellular calcium and helps regulate magnesium homeostasis. It is also involved in cytoskeletal organisation, cell adhesion, cell migration and organogenesis.
TRPM7 is also known as CHAK1, LTRPC7 and TRP-PLIK. Its earlier HGNC name was transient receptor potential cation channel, subfamily M, member 7. It sits in the LTrpC subfamily and is classed as an alpha kinase as well as a TRPM channel.
Defects in the TRPM7 gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam, and the gene may be associated with cardiac defects. Mouse and rat each have a Trpm7 ortholog; check the datasheet of any product for its validated reactivity.
Other TRPM subfamily channels that sit alongside TRPM7 in the transient receptor potential family.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96QT4; product specifications from Assay Genie datasheets.