CLEC4A
CLEC4A (C-type lectin domain family 4 member A, also known as DCIR, DDB27, CD367, hDCIR and CLECSF6) is a type 2 transmembrane protein of the C-type lectin superfamily. It is linked to inflammatory and immune responses and to HIV-1 interaction with dendritic cells. Browse Assay Genie's current range of CLEC4A research reagents below, or read on for the biology behind the target.
CLEC4A is a cell-membrane receptor that has been implicated in the interaction between HIV-1 and dendritic cells. In this setting it enhances virus binding and entry as well as infection. This activity depends on an ITIM motif-associated signal transduction pathway, which involves the phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases. The encoded protein is a type 2 transmembrane protein that may also play a role in inflammatory and immune responses more broadly.
The CLEC4A gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, including cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. Multiple transcript variants encoding distinct isoforms have been identified. The gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13, within the natural killer gene complex region. Mouse and rat both carry a Clec4a ortholog.
HGNC places CLEC4A in the CD molecules, C-type lectin domain containing and Dectin 2 cluster gene groups, and the protein is designated CD367. Earlier names include C-type lectin superfamily member 6 (CLECSF6), and it is widely referred to as DCIR (and hDCIR for the human protein). Researchers studying CLEC4A, whether the CLEC4A protein, its signalling partners or its role in dendritic cell biology, will find these aliases used interchangeably in the literature.
CLEC4A is involved in HIV-1 interaction with dendritic cells, enhancing virus binding, entry and infection.
Its activity requires an ITIM-associated pathway involving PTPN6, PTPN11, SYK, Src kinases and MAP kinases.
As a type 2 transmembrane C-type lectin, CLEC4A may contribute to inflammatory and immune responses.
CLEC4A belongs to the CTL/CTLD superfamily, whose members act in cell adhesion, cell-cell signalling and glycoprotein turnover.
CLEC4A is a cell-membrane C-type lectin receptor that may play a role in inflammatory and immune responses. It is involved in the interaction between HIV-1 and dendritic cells, where it enhances virus binding, entry and infection through an ITIM-associated signalling pathway.
CLEC4A is also called DCIR, hDCIR, DDB27, CD367 and CLECSF6. Its earlier name was C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6. Multiple transcript variants encoding distinct isoforms have been reported for the gene.
Yes. Both mouse and rat have a Clec4a ortholog. The human gene sits in the natural killer gene complex region of chromosome 12p13, alongside other C-type lectin superfamily members. Check the datasheet of any product for its validated reactivity.
Other C-type lectin domain family members, including receptors from the Dectin 2 cluster, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UMR7; product specifications from Assay Genie datasheets.