NRP2
NRP2 (neuropilin 2, also known as VEGF165R2) is a transmembrane receptor of the neuropilin family that binds class 3 semaphorins and interacts with vascular endothelial growth factor. It has been linked to cardiovascular development, axon guidance and tumorigenesis. Browse Assay Genie's current range of NRP2 research reagents below, or read on for the biology behind the target.
NRP2 is a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds the secreted semaphorins SEMA3C and SEMA3F, and it interacts with vascular endothelial growth factor (VEGF). Through these interactions it is thought to play a role in cardiovascular development, axon guidance and tumorigenesis, which makes it a frequent subject in vascular biology, neuroscience and cancer research.
UniProt lists neuropilin-2 as occurring in both membrane and secreted forms, and classifies it within the neuropilin family. The NRP2 gene is the human gene whose mouse and rat orthologues are both named Nrp2, so findings in rodent models can be compared directly with the human protein. An alternative name, VEGF165R2, reflects its association with VEGF signalling.
NRP2 also has a role in infection biology. It acts as a receptor for human cytomegalovirus pentamer-dependent entry into epithelial and endothelial cells, and it has been identified as a co-receptor that helps SARS-CoV-2, the virus that causes COVID-19, infect host cells. Researchers studying NRP2 therefore work across developmental signalling, tumour biology and virology, using tools such as an NRP2 antibody, an NRP2 ELISA kit or recombinant NRP2 protein to examine expression and function.
NRP2 may contribute to cardiovascular development, and its interaction with VEGF places it within vascular signalling studies.
NRP2 binds SEMA3C and SEMA3F, secreted semaphorins, and is implicated in axon guidance.
NRP2 may play a role in tumorigenesis, so it is examined in studies of tumour signalling and progression.
NRP2 is a receptor for human cytomegalovirus entry and a co-receptor for SARS-CoV-2 infection of host cells.
NRP2 is a transmembrane receptor of the neuropilin family. It binds SEMA3C and SEMA3F and interacts with VEGF, and it may play a role in cardiovascular development, axon guidance and tumorigenesis. It also serves as a viral entry receptor or co-receptor.
The HGNC-approved name is neuropilin 2, and UniProt names the protein Neuropilin-2. VEGF165R2 is a recorded alias. The gene symbol NRP2 is used for the human gene, and the mouse and rat orthologues are both called Nrp2.
Yes. UniProt reports that NRP2 acts as a receptor for human cytomegalovirus pentamer-dependent entry into epithelial and endothelial cells. NCBI Gene also describes it as a co-receptor for SARS-CoV-2 infection of host cells. Check the datasheet of any product for its validated reactivity.
Other neuropilin family members, semaphorin ligands and VEGF pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60462; product specifications from Assay Genie datasheets.