TIMM22
TIMM22 (translocase of inner mitochondrial membrane 22, also known as TIM22 or TEX4) is the essential core subunit of the TIM22 complex. It forms the voltage-activated, signal-gated channel that inserts multi-pass transmembrane proteins into the mitochondrial inner membrane. Browse Assay Genie's current range of TIMM22 research reagents below, or read on for the biology behind the target.
TIMM22 is an essential core component of the TIM22 complex, which mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Within this complex, the TIMM22 protein constitutes the voltage-activated and signal-gated channel. The complex forms a twin-pore translocase that uses the membrane potential as its external driving force, acting in two voltage-dependent steps.
According to the NCBI Gene summary, the TIM22 complex has six subunits, and the protein encoded by the TIMM22 gene is the subunit that represents the channel. UniProt places TIMM22 in the mitochondrion inner membrane and assigns it to the Tim17/Tim22/Tim23 family. HGNC classifies it in the TIM22 complex and Tim17 family gene groups. Mouse and rat each have a Timm22 ortholog.
The gene was previously named testis-expressed sequence 4 (hence the alias TEX4) and translocase of inner mitochondrial membrane 22 homolog (yeast), and the symbol TIM22 is still widely used. Its role in inserting membrane proteins into the inner membrane makes TIMM22 a useful target for studies of mitochondrial protein import, membrane biogenesis and the relationship between membrane potential and protein translocation. Researchers often study it alongside other translocase components such as TIMM17A, TIMM44 and TIMM50.
TIMM22 forms the channel of the TIM22 complex, which imports and inserts multi-pass transmembrane proteins into the mitochondrial inner membrane.
The twin-pore translocase uses membrane potential as its driving force in two voltage-dependent steps, making TIMM22 relevant to bioenergetic transport studies.
As an essential core component of the TIM22 complex, TIMM22 supports the insertion of transmembrane proteins that build the mitochondrial inner membrane.
TIMM22 is one of six subunits in the TIM22 complex and belongs to the Tim17/Tim22/Tim23 family, informing comparative studies of translocases.
TIMM22 is an essential core component of the TIM22 complex. It constitutes the voltage-activated and signal-gated channel that mediates import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, as part of a twin-pore translocase driven by membrane potential.
TIMM22 is also written TIM22 and TEX4. Previous names include testis-expressed sequence 4 and translocase of inner mitochondrial membrane 22 homolog (yeast). UniProt lists the protein as mitochondrial import inner membrane translocase subunit Tim22.
Yes. Mouse and rat both have a Timm22 ortholog, and the human protein belongs to the Tim17/Tim22/Tim23 family. Its former name referenced a yeast homolog. For reactivity with a given species, check the datasheet of any product for its validated reactivity.
Other mitochondrial inner membrane translocase subunits and Tim17 family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y584; product specifications from Assay Genie datasheets.