ZP2
ZP2 (zona pellucida glycoprotein 2, also known as ZPA) is a structural component of the zona pellucida, the extracellular matrix that surrounds the oocyte. It contributes to sperm binding and to the events of fertilisation and early development. Browse Assay Genie's current range of ZP2 research reagents below, or read on for the biology behind the target.
ZP2 is a component of the zona pellucida, an extracellular matrix surrounding oocytes that mediates sperm binding, induces the acrosome reaction and prevents post-fertilisation polyspermy. The zona pellucida is composed of three to four glycoproteins, ZP1, ZP2, ZP3 and ZP4. ZP2 may act as a secondary sperm receptor. According to the NCBI Gene summary, the glycosylated mature peptide is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa.
The ZP2 protein belongs to the ZP domain family and the ZPA subfamily, and is assigned to the HGNC gene group of zona pellucida glycoproteins. UniProt lists its subcellular locations as the zona pellucida and the cell membrane. The ZP2 gene undergoes alternative splicing, which results in multiple transcript variants. Mouse and rat both carry a Zp2 ortholog.
The zona pellucida surrounds the oocyte and the early embryo, and its three glycoproteins have distinct roles in fertilisation and preimplantation development. Female mice lacking this gene do not form a stable zona matrix and are sterile, which underlines its structural importance. The gene was previously named zona pellucida glycoprotein 2 (sperm receptor), and ZPA is a former symbol. ZP3 is another zona pellucida glycoprotein relevant to this system.
ZP2 is involved in sperm binding to the zona pellucida and in the penetration of acrosome-reacted spermatozoa.
ZP2 is a structural component of the zona pellucida, the matrix surrounding the oocyte and early embryo.
Female mice lacking Zp2 do not form a stable zona matrix and are sterile, making the gene relevant to fertility research.
The zona pellucida glycoproteins have distinct functions in fertilisation and preimplantation development, and ZP2 is one of them.
ZP2 is a component of the zona pellucida, the extracellular matrix around oocytes that mediates sperm binding, induces the acrosome reaction and helps prevent polyspermy after fertilisation. It may act as a secondary sperm receptor, binding and allowing penetration by acrosome-reacted spermatozoa.
The HGNC name is zona pellucida glycoprotein 2, and UniProt calls the protein zona pellucida sperm-binding protein 2. ZPA is a former symbol, and an earlier name was zona pellucida glycoprotein 2 (sperm receptor). Alternative splicing gives multiple transcript variants.
Mouse and rat both have a Zp2 ortholog. In mice, females lacking the gene do not form a stable zona matrix and are sterile, which shows its role in the zona pellucida. Check the datasheet of any product for its validated reactivity.
Other zona pellucida glycoproteins and related targets in fertilisation research with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q05996; product specifications from Assay Genie datasheets.