MT-ND5
MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5, also known as ND5, NAD5 or MTND5) is a core subunit of mitochondrial respiratory chain complex I. It supports electron transfer from NADH to ubiquinone and is needed for complex I assembly. Browse Assay Genie's current range of MT-ND5 research reagents below, or read on for the biology behind the target.
MT-ND5 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, also called complex I. Complex I catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as the electron acceptor. The MT-ND5 protein is essential for both the catalytic activity and the assembly of complex I. Consistent with this, NCBI Gene describes it as enabling NADH dehydrogenase (ubiquinone) activity and as involved in mitochondrial electron transport from NADH to ubiquinone and in mitochondrial respiratory chain complex I assembly.
The MT-ND5 gene is encoded in the mitochondrial genome rather than the nucleus, and it belongs to the HGNC groups for NADH:ubiquinone oxidoreductase core subunits and mitochondrially encoded protein-coding genes. The protein, UniProt name NADH-ubiquinone oxidoreductase chain 5, is a member of the complex I subunit 5 family. It sits in the mitochondrial inner membrane as part of respiratory chain complex I. Mouse and rat orthologues are designated Mtnd5 and Mt-nd5 respectively.
The gene has appeared in the literature under several names, including NADH dehydrogenase 5 and mitochondrially encoded NADH dehydrogenase 5, alongside the symbols ND5, NAD5 and MTND5. MT-ND5 is implicated in Leber hereditary optic neuropathy, Leigh disease and MELAS syndrome, which makes it a frequent subject in studies of mitochondrial disease and complex I function.
MT-ND5 is a core subunit required for the catalytic activity of complex I, so it is a natural focus for studies of NADH to ubiquinone electron transfer.
The protein is essential for assembling complex I, making it relevant to work on how the respiratory chain is built in the inner membrane.
MT-ND5 is implicated in Leber hereditary optic neuropathy, Leigh disease and MELAS syndrome, supporting investigation of mitochondrial disorders.
As a mitochondrially encoded respiratory chain gene, MT-ND5 is studied alongside other mtDNA-encoded subunits to understand how the mitochondrial genome shapes oxidative metabolism.
MT-ND5 is a core subunit of mitochondrial complex I, the NADH dehydrogenase of the respiratory chain. Complex I catalyses electron transfer from NADH to ubiquinone. MT-ND5 is essential for the catalytic activity and assembly of the complex, and it is located in the mitochondrial inner membrane.
Aliases and previous symbols include ND5, NAD5 and MTND5. Earlier names were NADH dehydrogenase 5 and mitochondrially encoded NADH dehydrogenase 5. UniProt lists the protein as NADH-ubiquinone oxidoreductase chain 5, a member of the complex I subunit 5 family, with EC number 7.1.1.2.
NCBI Gene reports that MT-ND5 is implicated in Leber hereditary optic neuropathy, Leigh disease and MELAS syndrome. Orthologues exist in mouse (Mtnd5) and rat (Mt-nd5). For any product, check the datasheet for its validated reactivity.
Other mitochondrially encoded respiratory chain and ATP synthase subunits with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P03915; product specifications from Assay Genie datasheets.