SEPTIN5
SEPTIN5 (septin 5; also CDCREL-1, HCDCREL-1, H5, PNUTL1 and SEPT5) is a filament-forming cytoskeletal GTPase of the septin family. It is linked to cytokinesis and to platelet secretion. Browse Assay Genie's current range of SEPTIN5 research reagents below, or read on for the biology behind the target.
SEPTIN5 is a filament-forming cytoskeletal GTPase. UniProt annotates it as possibly playing a role in cytokinesis and in platelet secretion. It belongs to the septin GTPase family within the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, and is found in the cytoplasm and the cytoskeleton.
The SEPTIN5 gene is a member of the septin family of nucleotide-binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila and mouse, and appear to regulate cytoskeletal organisation. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Mouse and rat both carry a Septin5 ortholog. Alternative splicing gives multiple transcript variants. A non-consensus polyA signal (AACAAT) also allows read-through transcription into the neighbouring gene GP1BB (platelet glycoprotein Ib), producing larger non-coding transcripts.
The gene maps to 22q11, a region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukaemia. The protein was formerly known as peanut-like 1 (Drosophila), and the aliases CDCREL-1, HCDCREL-1, H5, PNUTL1 and SEPT5 appear in the literature. HGNC now lists the symbol SEPTIN5 within the Septins gene group.
Septins regulate cytoskeletal organisation, and disrupting septin function disturbs cytokinesis, making SEPTIN5 relevant to cell division studies.
UniProt notes a possible role for SEPTIN5 in platelet secretion, and its gene lies beside GP1BB, encoding platelet glycoprotein Ib.
A translocation joining the MLL gene and SEPTIN5 has been reported in patients with acute myeloid leukaemia.
The SEPTIN5 gene maps to 22q11, a region frequently deleted in DiGeorge and velocardiofacial syndromes.
SEPTIN5 is a filament-forming cytoskeletal GTPase. According to UniProt it may play a role in cytokinesis and in platelet secretion. Septins in general appear to regulate cytoskeletal organisation, and disrupting their function produces large multinucleate or polyploid cells.
SEPTIN5 is also known as CDCREL-1, HCDCREL-1, H5, PNUTL1 and SEPT5, and was previously named peanut-like 1 (Drosophila). Alternative splicing yields multiple transcript variants, and read-through into the neighbouring GP1BB gene produces larger non-coding transcripts.
Septins are highly conserved in yeast, Drosophila and mouse, and mouse and rat each have a Septin5 ortholog. The human gene maps to 22q11, and an MLL–SEPTIN5 translocation has been reported in acute myeloid leukaemia. Check the datasheet of any product for its validated reactivity.
Other septin GTPases involved in cytoskeletal organisation and cytokinesis, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99719; product specifications from Assay Genie datasheets.