MYO7B
MYO7B (myosin VIIB) is an unconventional, actin-based myosin motor with ATPase activity. It localises to the microvilli of epithelial brush borders, where it helps organise the intermicrovillar adhesion complex. Browse Assay Genie's current range of MYO7B research reagents below, or read on for the biology behind the target.
Myosins are actin-based motor molecules with ATPase activity, and MYO7B belongs to the myosin family within the TRAFAC class myosin-kinesin ATPase superfamily. Like other myosins, its highly divergent tail is presumed to bind membranous compartments, which would then be moved relative to actin filaments. MYO7B is part of the intermicrovillar adhesion complex (IMAC), where it plays a role in epithelial brush border differentiation by controlling microvilli organisation and length. It may link the complex to the actin core bundle of microvilli.
The MYO7B protein is found in the brush border microvilli of epithelial cells in the intestines and kidneys. It is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. It also aids the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. Researchers studying the MYO7B gene or MYO7B protein therefore often do so in the context of epithelial polarity and microvillar architecture.
HGNC places myosin VIIB in the class VII myosin heavy chain group. It is also classed among FERM domain containing and SH3 domain containing proteins. The mouse ortholog is Myo7b, which allows the biology of this motor to be examined in murine models.
MYO7B contributes to epithelial brush border differentiation, controlling the organisation and length of microvilli.
As part of the IMAC, MYO7B helps accumulate components such as harmonin and ANKS4B needed for normal brush border action.
An actin-based motor with ATPase activity, MYO7B may link adhesion complexes to the actin core bundle of microvilli.
MYO7B is found in brush border microvilli of intestinal and kidney epithelial cells, where it supports proper microvilli function.
MYO7B is an actin-based motor with ATPase activity. As part of the intermicrovillar adhesion complex, it plays a role in epithelial brush border differentiation, controlling microvilli organisation and length. It may link the complex to the actin core bundle of microvilli, and it helps link protocadherins to actin.
MYO7B is the HGNC symbol for myosin VIIB, and UniProt names the protein unconventional myosin-VIIb. No alternative aliases or previous symbols are recorded in the data used here, so the gene and protein are generally referred to by these names.
MYO7B localises to the cytoplasmic cytoskeleton and to microvilli, particularly the brush border of intestinal and kidney epithelial cells. The mouse ortholog is Myo7b. Check the datasheet of any product for its validated reactivity.
Other myosin family members and related cytoskeletal motor proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6PIF6; product specifications from Assay Genie datasheets.