SLC30A10
SLC30A10 (solute carrier family 30 member 10, also known as ZnT-10, ZNT10, ZNT8 or ZRC1) is a plasma membrane calcium:manganese antiporter that drives manganese efflux from the cell. It is required for intracellular manganese homeostasis. Browse Assay Genie's current range of SLC30A10 research reagents below, or read on for the biology behind the target.
SLC30A10 is a calcium:manganese antiporter of the plasma membrane. It mediates the efflux of intracellular manganese, coupled to an active exchange of extracellular calcium. Manganese is an essential cation for several enzymes, including some that are crucial for the metabolism of neurotransmitters and for other neuronal metabolic pathways. It can also be cytotoxic, inducing oxidative stress, mitochondrial dysfunction and apoptosis, so its intracellular level needs tight control. The SLC30A10 protein is required for that control. It could also act as an intracellular zinc ion transporter, directly regulating zinc homeostasis and, more indirectly, various signalling pathways and biological processes.
The protein belongs to the cation diffusion facilitator (CDF) transporter family (TC 2.A.4) and to the SLC30A subfamily, within the HGNC solute carrier family 30 gene group. Besides the cell membrane, UniProt annotates it at the Golgi apparatus membrane, the recycling endosome membrane and the early endosome membrane. The SLC30A10 gene is highly expressed in the liver and is inducible by manganese. Its product has higher specificity for manganese than for zinc. Alternatively spliced transcript variants have been observed.
Loss-of-function mutations in the SLC30A10 gene result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism, which makes the transporter a focus for studies of manganese handling and neurological disease. The gene was previously named solute carrier family 30, member 10, and is also referred to as ZnT-10. The mouse ortholog is Slc30a10.
SLC30A10 mediates manganese efflux and is required for intracellular manganese homeostasis, making it central to studies of how cells regulate this essential cation.
Loss-of-function mutations in SLC30A10 are associated with dystonia and adult-onset parkinsonism, linking the transporter to movement disorder biology.
Excess manganese can induce oxidative stress, mitochondrial dysfunction and apoptosis, so SLC30A10 is relevant to cytotoxicity and cell-stress studies.
SLC30A10 may also transport zinc, regulating zinc homeostasis and signalling, and is studied alongside other SLC30A cation diffusion facilitators.
SLC30A10 is a plasma membrane calcium:manganese antiporter. It exports intracellular manganese in exchange for extracellular calcium and is required for manganese homeostasis. It could also transport zinc ions, although it shows higher specificity for manganese than for zinc.
The HGNC name is solute carrier family 30 member 10, previously solute carrier family 30, member 10. Aliases include ZnT-10, ZNT10, ZNT8, ZRC1 and DKFZp547M236. UniProt lists the protein as calcium/manganese antiporter SLC30A10. Alternatively spliced transcript variants have been observed for the gene.
Yes. According to the NCBI Gene summary, loss-of-function mutations in SLC30A10 give a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. The gene is highly expressed in the liver and is inducible by manganese. Mouse has an ortholog, Slc30a10.
Other solute carrier family members, including the metal ion transporter SLC11A2, with related research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6XR72; product specifications from Assay Genie datasheets.