FGFRL1
FGFRL1 (fibroblast growth factor receptor like 1, also known as FGFR5) is a membrane protein related to the fibroblast growth factor receptor family. Unlike its relatives it lacks a cytoplasmic tyrosine kinase domain, and it has a negative effect on cell proliferation. Browse Assay Genie's current range of FGFRL1 research reagents below, or read on for the biology behind the target.
FGFRL1 is a member of the fibroblast growth factor receptor (FGFR) family. The amino acid sequence of FGFR family members is highly conserved between members and throughout evolution, while individual members differ in their ligand affinities and tissue distribution. UniProt annotates FGFRL1 as having a negative effect on cell proliferation.
A full-length representative FGFR consists of an extracellular region made up of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals that ultimately influence mitogenesis and differentiation. FGFRL1 differs markedly from the other family members because it has no cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signalling.
The FGFRL1 gene is also known by the alias FGFR5, and HGNC places it in the I-set domain containing, Ig-like cell adhesion molecule and fibroblast growth factor receptor gene groups. Multiple alternatively spliced transcript variants have been described, and all of them encode the same isoform. Mouse and rat orthologs are both named Fgfrl1, which allows comparative work in rodent models.
FGFRL1 is an FGFR-related receptor whose extracellular region interacts with fibroblast growth factors, making it relevant to studies of FGF-driven signalling.
UniProt annotates FGFRL1 as having a negative effect on cell proliferation, so it is of interest in studies of growth regulation.
Lacking a tyrosine kinase domain, FGFRL1 could interact with other family members and potentially inhibit signalling, a question for receptor interaction research.
FGFR family signalling ultimately influences mitogenesis and differentiation, and FGFRL1 offers a kinase-less member for dissecting these processes.
FGFRL1 is a transmembrane receptor with a negative effect on cell proliferation. It has an extracellular region that can interact with fibroblast growth factors but no cytoplasmic tyrosine kinase domain, so it could interact with other family members and potentially inhibit signalling.
Yes. FGFR5 is an alias for FGFRL1, whose HGNC name is fibroblast growth factor receptor like 1. Several alternatively spliced transcript variants exist, but all encode the same protein isoform.
Other FGFR family members carry a cytoplasmic tyrosine kinase domain, whereas FGFRL1 lacks it. Sequence is highly conserved across the family and through evolution, and mouse and rat both have an ortholog called Fgfrl1. Check the datasheet of any product for its validated reactivity.
Other fibroblast growth factor receptors and FGF ligands that act in related signalling pathways.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N441; product specifications from Assay Genie datasheets.