ADORA1
ADORA1 (adenosine A1 receptor, also known as RDC7) is a cell membrane receptor for adenosine and a member of the G protein-coupled receptor 1 family. It signals through G proteins that inhibit adenylyl cyclase. Browse Assay Genie's current range of ADORA1 research reagents below, or read on for the biology behind the target.
ADORA1 is a receptor for adenosine. Its activity is mediated by G proteins such as GNAI2, which inhibit adenylyl cyclase. The A1 receptor therefore couples extracellular adenosine to changes in intracellular cyclic nucleotide signalling at the cell membrane, where the protein is located.
The ADORA1 gene encodes a protein that belongs to the G protein-coupled receptor 1 family. It is one of three types of adenosine receptor, each with a specific pattern of ligand binding and tissue distribution, which together regulate a diverse set of physiological functions. Transcript variants with alternative splicing in the 5' UTR have been reported for this gene. Orthologous genes, named Adora1, are present in mouse and rat, which allows the receptor to be studied in rodent models.
Beyond its signalling mechanism, the A1 receptor has been linked to several biological processes. According to the NCBI Gene summary, it plays a role in the fertilisation process, and animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. HGNC lists the gene in the adenosine receptors group, and RDC7 is recorded as an alias. Researchers working on adenosine signalling often compare ADORA1 with the other adenosine receptor subtypes, such as ADORA2B and ADORA3, to separate the contribution of each receptor.
ADORA1 couples to G proteins such as GNAI2 to inhibit adenylyl cyclase, making it a model for studying adenosine-driven G protein signalling.
The A1 receptor is reported to play a role in the fertilisation process, making it relevant to studies of reproduction.
Animal studies suggest that A1 receptors contribute to kidney function, supporting investigation of ADORA1 in renal physiology.
Animal studies also point to a role for A1 receptors in ethanol intoxication, which is of interest in neuropharmacology research.
ADORA1 is a receptor for adenosine at the cell membrane. Its activity is mediated by G proteins such as GNAI2, which inhibit adenylyl cyclase. NCBI Gene also reports a role in fertilisation, and animal studies suggest roles in kidney function and ethanol intoxication.
The HGNC name is adenosine A1 receptor, and UniProt calls the protein adenosine receptor A1. RDC7 is a recorded alias. NCBI Gene notes transcript variants with alternative splicing in the 5' UTR, so more than one transcript can arise from the gene.
Yes. Mouse and rat each have an orthologous gene named Adora1, so the receptor can be studied in rodent models. ADORA1 is one of three adenosine receptor types in humans; check the datasheet of any product for its validated reactivity.
Other adenosine receptor subtypes that act alongside ADORA1 in adenosine signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30542; product specifications from Assay Genie datasheets.